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Chemical Structure| 1614246-83-1 Chemical Structure| 1614246-83-1

Structure of 1614246-83-1

Chemical Structure| 1614246-83-1

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Product Details of [ 1614246-83-1 ]

CAS No. :1614246-83-1
Formula : C14H11ClF2O2S
M.W : 316.75
SMILES Code : FC1=CC=C(Cl)C=C1C2=CC=C(S(=O)(CC)=O)C=C2F
MDL No. :MFCD30470869

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Application In Synthesis of [ 1614246-83-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1614246-83-1 ]

[ 1614246-83-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 116272-42-5 ]
  • [ 1614246-56-8 ]
  • [ 1614246-83-1 ]
YieldReaction ConditionsOperation in experiment
28% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; water; at 80℃; for 2h; A solution of 2-(4-(ethylsulfonyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Preparation 45, 1.77 g, 5.64 mmol), <strong>[116272-42-5]4-chloro-1-fluoro-2-iodobenzene</strong> (1.28 g, 5.00 mmol), and sodium carbonate (1.59 g, 15.00 mmol) in dioxane (40 mL) and water (10 mL) was degassed. Tetrakis(triphenylphosphine)palladium(0) (577 mg, 0.50 mmol) was added and the mixture was degassed twice more, and the reaction warmed to 80 C. for 2 hours. The reaction was cooled and diluted with EtOAc (50 mL) and water (50 mL), the layers separated and the aqueous extracted with EtOAc (2*30 mL). The combined organic layers were washed with brine (30 mL), dried over MgSO4 and the solvent removed in vacuo. The crude was purified by silica gel column chromatography eluting with EtOAc:heptane 1:19 to 1:1 to give the title compound as a colourless oil 28% yield, 443 mg. 1H NMR (400 MHz, CDCl3): δ ppm 1.34 (t, 3H), 3.18 (q, 2H), 7.16 (m, 1H), 7.38 (m, 2H), 7.60 (m, 1H), 7.73 (m, 1H), 7.78 (m, 1H). 19F NMR (376 MHz, CDCl3): δ -110.2 (m, 1F), -116.9 (m, 1F).
 

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