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Chemical Structure| 1610472-53-1 Chemical Structure| 1610472-53-1

Structure of 1610472-53-1

Chemical Structure| 1610472-53-1

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Product Details of [ 1610472-53-1 ]

CAS No. :1610472-53-1
Formula : C8H5Br2FO2
M.W : 311.93
SMILES Code : O=C(O)C1=CC(CBr)=C(F)C=C1Br

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Application In Synthesis of [ 1610472-53-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1610472-53-1 ]

[ 1610472-53-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1003709-39-4 ]
  • [ 1610472-53-1 ]
YieldReaction ConditionsOperation in experiment
74% With N-Bromosuccinimide; dibenzoyl peroxide; In acetonitrile; for 4.0h;Reflux; A mixture of 2-bromo-4-fluoro-5-methyl-benzoic acid (0.5 g, 2.14 mmol), N-bromosuccinimide (381 mg, 2.15 mmol) and benzoyl peroxide (10 mg, 0.04 mmol) in CH3CN (10 mL) was heated at reflux for 4 h. The reaction mixture was cooled to 0 C and 5% aqueous Na2S203 was added. The CH3CN was evaporated and the residue was extracted with EtOAc (3 x 100 mL). The combined organic phases were dried (Na2S04), filtered, and evaporated. The residue was purified by chromatography (silica gel, 2-20% EtOAc/hexane) to give 2-bromo-5-bromomethyl- 4-fluoro-benzoic acid (500 mg, 74%). MS calcd. for C8H6Br2F02 [(M-H) ] 309, obsd. 308.6.
 

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