Name: 157069-48-2|4-(4H-1,2,4-Triazol-4-yl)benzoic acid|98%
Brand: Ambeed
SKU: A891756
Price: 17.0 USD
Availability: InStock
Rating: 98 (26 reviews)

1
[ 150-13-0 ]
[ 122-51-0 ]
[ 624-84-0 ]
[ 157069-48-2 ]

Yield	Reaction Conditions	Operation in experiment
55%

Reference： [1]Zou, Ru-Qiang; Cai, Li-Zhen; Guo, Guo-Cong [Journal of Molecular Structure, 2005, vol. 737, # 2-3, p. 125 - 129]

2
[ 203521-17-9 ]
[ 157069-48-2 ]
1-(6-chloronaphthalene-2-sulfonyl)-4-[4-(1,2,4-triazol-4-yl)benzoyl]piperazine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
54 mg	With benzotriazol-1-ol; triethylamine In N,N-dimethyl-formamide

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - US6359134, 2002, B1 Location in patent: Example 51

3
[ 207798-96-7 ]
[ 157069-48-2 ]
1-(6-bromonaphthalene-2-sulfonyl)-4-[4-(1,2,4-triazol-1-yl)benzoyl]piperazine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
139 mg	With benzotriazol-1-ol; triethylamine In N,N-dimethyl-formamide

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - US6359134, 2002, B1 Location in patent: Example 66

4
[ 167626-25-7 ]
[ 157069-48-2 ]

Yield	Reaction Conditions	Operation in experiment
99%	Stage #1: 4-(4H-1,2,4-triazol-4-yl)benzoic acid ethyl ester With water; sodium hydroxide In ethanol for 0.5h; Reflux; Stage #2: With hydrogenchloride In water	88 Ester 124 (6.8 g, 31.3 mmol) was dispersed into ethanol (70 ml), 1N sodium hydroxide (70 ml) was added, heated and refluxed for 30 minutes. After reaction ended, the solvent was distilled in vacuum, and the residu obtained was dissolved in water. 1N hydrochloric acid (70 ml) was added, precipitated colorless solid was filtered out, washed with water and dried in vacuum, yielding 125 (5.88 g, 99%). > mp330°C APCI-MS m/z 190[M+H]+ IR(Nujol) 1692, 1609cm-1
	With sodium hydroxide In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol	R.6 Reference Example 6 Reference Example 6 5.5 ml of a 5N aqueous sodium hydroxide solution was added to a solution of 1.2 g of ethyl 4-(1,2,4-triazol-4-yl)benzoate in 15 ml of ethanol. The mixture was stirred at 50°-60° C. for 1 hour. The reaction mixture was concentrated under reduced pressure. To the residue was added ice water. The mixture was made acidic with acetic acid. The resulting crystals were collected by filtration, water-washed, and dried to obtain 0.95 g of 4-(1,2,4-triazol-4-yl)benzoic acid as a white powder. Melting point: 300° C. or above 1 H-NMR (250 MHz, DMSO-d6) δ ppm: 7.87 (2H, d, J=8.5 Hz), 8.09 (2H, d, J=8.5 Hz), 9.24 (2H, s), 13.21 (1H, brs)
275 mg	Stage #1: 4-(4H-1,2,4-triazol-4-yl)benzoic acid ethyl ester With sodium hydroxide In tetrahydrofuran; etanol at 20℃; for 2h; Stage #2: With hydrogenchloride In water

Reference： [1]Current Patent Assignee: TOHOKU UNIVERSITY - EP2103611, 2009, A1 Location in patent: Page/Page column 83
[2]Current Patent Assignee: OTSUKA HOLDINGS CO LTD - US5656642, 1997, A
[3]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - US6359134, 2002, B1 Location in patent: Referential example 17

5
N,N-dimethylformamide azine dihydrochloride [ No CAS ]
[ 150-13-0 ]
[ 157069-48-2 ]

Yield	Reaction Conditions	Operation in experiment
68%	In benzene for 7h; Heating;

Reference： [1]Naik, Anil D.; Marchand-Brynaert, Jacqueline; Garcia, Yann [Synthesis, 2008, # 1, p. 149 - 154]

6
[ 7732-18-5 ]
cobalt(II) nitrate [ No CAS ]
[ 157069-48-2 ]
[Co(4-(p-benzoxy)-1,2,4-triazole(-1H))2(H₂O)4]*10H₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	With NaOH In water High Pressure; aq. soln. of Co salt reacted with ligand, NaOH added (pH 7), stirred at room temp. for 3 h, sealed at 140°C for 3 d; filtered, dried (air); elem. anal.;

Reference： [1]Zou, Ru-Qiang; Cai, Li-Zhen; Guo, Guo-Cong [Journal of Molecular Structure, 2005, vol. 737, # 2-3, p. 125 - 129]

7
[ 7732-18-5 ]
[ 6147-53-1 ]
[ 157069-48-2 ]
[ 1004770-87-9 ]

Yield	Reaction Conditions	Operation in experiment
60%	In water High Pressure; Co salt, acid and water in Teflon vessel placed in steel bomb; heated to413 K for 24 h; mixt. cooled slowly to room temp. over 72 h;

Reference： [1]Lukashuk, Liliana V.; Lysenko, Andrey B.; Rusanov, Eduard B.; Chernega, Alexander N.; Domasevitch, Konstantin V. [Acta Crystallographica, Section C: Crystal Structure Communications, 2007, vol. 63, # 4, p. m140-m143]

8
[ 1036394-78-1 ]
[ 157069-48-2 ]
[ 1036394-80-5 ]

Yield	Reaction Conditions	Operation in experiment
54%	Stage #1: 4-(4′-carboxyphenyl)-1,2,4-triazole With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: C₁₆H₁₈FNO₃ In N,N-dimethyl-formamide at 20 - 50℃;	88 Carbonic acid 125 (1.89 g, 10 mmol) was dissolved in dried dimethylformamide (50 ml), and further 1-hydroxybenzotriazole (2.026 g, 15 mmol), water-soluble carbodiimide hydrochloride (WSC-HCl) (2.875 g, 15 mmol) and triethylamine (2.02 g, 20 mmol) were added, and stirred at room temperature for 2 hours to react. Next, 128 (2.92 g, 10 mmol) was added to the reaction solution, the temperature raised to 50°C, and it was further reacted for 3 hours. After cooling down, the reaction solution was poured into water, the product was extracted with ethyl acetate, washed with water and saturated saline solution, and dried with anhydrous magnesium sulfate. After solvent distilled, the obtained crude product was purified with column chromatography (silica gel BW300: eluate chloroform: methanol = 20:1), yielding 129 (2.52 g, 54%). mp 175-177° C IR(Nujol) 3312, 1652, 1610cm-1 APCI-MS m/z 463[M+H]+

Reference： [1]Current Patent Assignee: TOHOKU UNIVERSITY - EP2103611, 2009, A1 Location in patent: Page/Page column 83-84

9
[ 67-56-1 ]
holmium(III) chloride hexahydrate [ No CAS ]
[ 157069-48-2 ]
[Ho(III)4(μ3-OH)2(μ3-O)2(4-(4-carboxyphenyl)-1,2,4-triazole(-1H))6(MeOH)6(H2O)]2*14CH3OH [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
13.1%	With NaN₃ In methanol; N,N-dimethyl-formamide soln. of NaN3 and ligand in DMF-MeOH added slowly to soln. of Ho salt inMeOH; stirred at room temp. for 15 min; filtered; crystd. from filtrate for several d;

Reference： [1]Savard, Didier; Lin, Po-Heng; Burchell, Tara J.; Korobkov, Ilia; Wernsdorfer, Wolfgang; Clerac, Rodolphe; Murugesu, Muralee [Inorganic Chemistry, 2009, vol. 48, # 24, p. 11748 - 11754]

10
[ 67-56-1 ]
dysprosium(III) chloride hexahydrate [ No CAS ]
[ 157069-48-2 ]
[Dy(III)4(μ3-OH)2(μ3-O)2(4-(4-carboxyphenyl)-1,2,4-triazole(-1H))6(MeOH)6(H2O)]2*15CH3OH [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	With NaN₃ In methanol; N,N-dimethyl-formamide soln. of NaN3 and ligand in DMF-MeOH added slowly to soln. of Dy salt inMeOH; stirred at room temp. for 15 min; filtered; crystd. from filtrate for several d;

Reference： [1]Savard, Didier; Lin, Po-Heng; Burchell, Tara J.; Korobkov, Ilia; Wernsdorfer, Wolfgang; Clerac, Rodolphe; Murugesu, Muralee [Inorganic Chemistry, 2009, vol. 48, # 24, p. 11748 - 11754]

11
[ 67-56-1 ]
terbium(III) chloride hexahydrate [ No CAS ]
[ 157069-48-2 ]
[Tb(III)4(μ3-OH)2(μ3-O)2(4-(4-carboxyphenyl)-1,2,4-triazole(-1H))6(MeOH)6(H2O)]2*18CH3OH [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
23.3%	With NaN₃ In methanol; N,N-dimethyl-formamide soln. of NaN3 and ligand in DMF-MeOH added slowly to soln. of Tb salt inMeOH; stirred at room temp. for 15 min; filtered; crystd. from filtrate for several d;

Reference： [1]Savard, Didier; Lin, Po-Heng; Burchell, Tara J.; Korobkov, Ilia; Wernsdorfer, Wolfgang; Clerac, Rodolphe; Murugesu, Muralee [Inorganic Chemistry, 2009, vol. 48, # 24, p. 11748 - 11754]

12
[ 16114-05-9 ]
[ 150-13-0 ]
[ 157069-48-2 ]

Yield	Reaction Conditions	Operation in experiment
70%	With toluene-4-sulfonic acid In 5,5-dimethyl-1,3-cyclohexadiene for 24h; Inert atmosphere; Reflux;

Reference： [1]Lässig, Daniel; Lincke, Jörg; Krautscheid, Harald [Tetrahedron Letters, 2010, vol. 51, # 4, p. 653 - 656]

13
manganese(II) chloride tetrahydrate [ No CAS ]
[ 7732-18-5 ]
[ 157069-48-2 ]
[ 1295506-83-0 ]

Yield	Reaction Conditions	Operation in experiment
75%	With NEt₃; HNO₃ In water; N,N-dimethyl-formamide High Pressure; soln. of triazole deriv. in DMF with NEt3 mixed with aq. MnCl2*4H2O at room temp.; 3 M HNO3 added, then EtOH added; soln. sealed in stainless steel reactor, heated at 85°C for 72 h; cooled to room temp.; filtered, washed with DMF and EtOH; elem. anal.;

Reference： [1]Song, Jiang-Feng; Zhou, Rui-Sha; Zhang, Jia; Xu, Chun-Yan; Li, Yan-Bing; Wang, Biao-Bing [Zeitschrift fur Anorganische und Allgemeine Chemie, 2011, vol. 637, # 5, p. 589 - 595]

14
copper(ll) sulfate pentahydrate [ No CAS ]
[ 7732-18-5 ]
[ 157069-48-2 ]
[Cu(μ-4-(4-carboxyphenyl)-1,2,4-triazole(-1H))(μ-OH)(H2O)2]*2H2O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70%	With NEt₃; HNO₃ In water; N,N-dimethyl-formamide High Pressure; soln. of triazole deriv. in DMF with NEt3 mixed with aq. CuSO4*5H2O at room temp.; 3 M HNO3 added, then EtOH added; soln. sealed in stainless steel reactor, heated at 85°C for 72 h; cooled to room temp.; filtered, washed with DMF and EtOH; elem. anal.;

Reference： [1]Song, Jiang-Feng; Zhou, Rui-Sha; Zhang, Jia; Xu, Chun-Yan; Li, Yan-Bing; Wang, Biao-Bing [Zeitschrift fur Anorganische und Allgemeine Chemie, 2011, vol. 637, # 5, p. 589 - 595]

15
cobalt(II) chloride hexahydrate [ No CAS ]
[ 7732-18-5 ]
[ 157069-48-2 ]
[ 1004770-87-9 ]

Yield	Reaction Conditions	Operation in experiment
90%	With NEt₃; HNO₃ In water; N,N-dimethyl-formamide High Pressure; soln. of triazole deriv. in DMF with NEt3 mixed with aq. CoCl2*6H2O at room temp.; 3 M HNO3 added, then EtOH added; soln. sealed in stainless steel reactor, heated at 85°C for 72 h; cooled to room temp.; filtered, washed with DMF and EtOH; elem. anal.;

Reference： [1]Song, Jiang-Feng; Zhou, Rui-Sha; Zhang, Jia; Xu, Chun-Yan; Li, Yan-Bing; Wang, Biao-Bing [Zeitschrift fur Anorganische und Allgemeine Chemie, 2011, vol. 637, # 5, p. 589 - 595]

16
[ 29604-34-0 ]
[ 64-17-5 ]
[ 33513-42-7 ]
[ 157069-48-2 ]
[Zn(4-(4-carboxyphenyl)-1,2,4-triazole(-1H))2]*0.5DMF*EtOH [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
58%	With NEt₃; HNO₃ In water; N,N-dimethyl-formamide High Pressure; soln. of triazole deriv. in DMF with NEt3 mixed with aq. ZnCl2*6H2O at room temp.; 3 M HNO3 added, then EtOH added; soln. sealed in stainless steel reactor, heated at 85°C for 72 h; cooled to room temp.; filtered, washed with DMF and EtOH; elem. anal.;

Reference： [1]Song, Jiang-Feng; Zhou, Rui-Sha; Zhang, Jia; Xu, Chun-Yan; Li, Yan-Bing; Wang, Biao-Bing [Zeitschrift fur Anorganische und Allgemeine Chemie, 2011, vol. 637, # 5, p. 589 - 595]

17
sodium azide [ No CAS ]
cobalt(II) nitrate hexahydrate [ No CAS ]
[ 157069-48-2 ]
[ 1437782-71-2 ]

Yield	Reaction Conditions	Operation in experiment
58%	In water at 120℃; for 72h; Autoclave; High pressure;

Reference： [1]Aharen, Tomoko; Habib, Fatemah; Korobkov, Ilia; Burchell, Tara J.; Guillet-Nicolas, Rémy; Kleiz, Fredy; Murugesu, Muralee [Dalton Transactions, 2013, vol. 42, # 21, p. 7795 - 7802]

18
[ 628-36-4 ]
[ 150-13-0 ]
[ 122-51-0 ]
[ 624-84-0 ]
[ 157069-48-2 ]

Reference： [1]Dalton Transactions,2013,vol. 42,p. 7795 - 7802

19
cobalt(II) nitrate hexahydrate [ No CAS ]
[ 7732-18-5 ]
[ 33513-42-7 ]
[ 157069-48-2 ]
[Co3(μ3-O)(OH)(4-(4′-carboxyphenyl)-1,2,4-triazole-H)3(H2O)2]n·xH2O·yDMF [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
18%	In ethanol at 90℃; for 24h;

Reference： [1]Aharen, Tomoko; Habib, Fatemah; Korobkov, Ilia; Burchell, Tara J.; Guillet-Nicolas, Rémy; Kleiz, Fredy; Murugesu, Muralee [Dalton Transactions, 2013, vol. 42, # 21, p. 7795 - 7802]

20
[ 7647-01-0 ]
cobalt(II) nitrate hexahydrate [ No CAS ]
[ 7732-18-5 ]
[ 157069-48-2 ]
[Co(II)8(OH)6(4-(4'-carboxyphenyl)-1,2,4-triazole-1H)6][CoCl₄]2*2H₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
126 mg	In ethanol; water; N,N-dimethyl-formamide at 150℃; for 24h; Autoclave;

Reference： [1]Holmberg, Rebecca J.; Kay, Marika; Korobkov, Ilia; Kadantsev, Eugene; Boyd, Peter G.; Aharen, Tomoko; Desgreniers, Serge; Woo, Tom K.; Murugesu, Muralee [Chemical Communications, 2014, vol. 50, # 40, p. 5333 - 5335]

21
[ 628-36-4 ]
[ 150-13-0 ]
[ 157069-48-2 ]

Reference： [1]Chemical Communications,2014,vol. 50,p. 5333 - 5335

22
cadmium(II) acetate [ No CAS ]
[ 7732-18-5 ]
[ 157069-48-2 ]
[Cd₂(μ₃-OH)₂(4-(4-carboxyphenyl)-1,2,4-triazole)₂]·(H₂O)}_n [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	In ethanol at 170℃; for 72h; Autoclave; High pressure;

Reference： [1]Li, Teng; Yang, Jian; Hong, Xu-Jia; Ou, Yan-Jun; Gu, Zhi-Gang; Cai, Yue-Peng [CrystEngComm, 2014, vol. 16, # 19, p. 3848 - 3852]

23
[ 872-50-4 ]
copper(II) nitrate trihydrate [ No CAS ]
[ 157069-48-2 ]
[(Cu₄Cl)(4-(4-carboxyphenyl)-1,2,4-triazole)₄(H₂O)₄]*3NO₃*5(N-methyl-2-pyrrolidone)*3.5H₂O}_n [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
45%	With hydrogenchloride In methanol; water at 80℃; for 48h; High pressure;

Reference： [1]Chen, Di-Ming; Shi, Wei; Cheng, Peng [Chemical Communications, 2015, vol. 51, # 2, p. 370 - 372]

24
[ 67-56-1 ]
copper(II) choride dihydrate [ No CAS ]
[ 7732-18-5 ]
[ 75-05-8 ]
[ 157069-48-2 ]
[Cu8(4-(4-carboxyphenyl)-1,2,4-triazole(-H))4Cl4(μ3-OH)2(μ4-O)2]Cl2·4H2O·2CH3CN·3MeOH}n [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	at 120℃; for 72h; High pressure; Autoclave;

Reference： [1]Chen, Di-Ming; Ma, Jian-Gong; Cheng, Peng [Dalton Transactions, 2015, vol. 44, # 19, p. 8926 - 8931]

25
[ 505-22-6 ]
copper(II) choride dihydrate [ No CAS ]
[ 7732-18-5 ]
[ 33513-42-7 ]
[ 157069-48-2 ]
[Cu4(4-(4-carboxyphenyl)-1,2,4-triazole(-H))4Cl4]·2DMF·dioxane·3H2O}n [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
30%	at 120℃; for 72h; High pressure; Autoclave;

Reference： [1]Chen, Di-Ming; Ma, Jian-Gong; Cheng, Peng [Dalton Transactions, 2015, vol. 44, # 19, p. 8926 - 8931]

26
copper(II) choride dihydrate [ No CAS ]
[ 7732-18-5 ]
[ 75-05-8 ]
[ 157069-48-2 ]
[Cu8(4-(4-carboxyphenyl)-1,2,4-triazole(-H))4(4-(4-carboxyphenyl)-1,2,4-triazole)2Cl7-(μ3-OH)2(H2O)4]Cl3·4CH3CN}n [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	at 120℃; for 72h; High pressure; Autoclave;

Reference： [1]Chen, Di-Ming; Ma, Jian-Gong; Cheng, Peng [Dalton Transactions, 2015, vol. 44, # 19, p. 8926 - 8931]

27
copper(II) nitrate trihydrate [ No CAS ]
[ 64-17-5 ]
[ 7732-18-5 ]
[ 157069-48-2 ]
3Cu⁽²⁺⁾*4C₉H₆N₃O₂^(1-)*NO₃^(1-)*7H₂O*C₂H₆O*HO^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	at 120℃; for 48h; Autoclave;

Reference： [1]Chen, Di-Ming; Zhang, Xiao-Ping; Shi, Wei; Cheng, Peng [Inorganic Chemistry, 2015, vol. 54, # 11, p. 5512 - 5518]

28
[ 127-19-5 ]
[ 7732-18-5 ]
[ 7646-85-7 ]
[ 157069-48-2 ]
Zn⁽²⁺⁾*2C₉H₆N₃O₂^(1-)*C₄H₉NO*3.5H₂O [ No CAS ]