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Chemistry
Organic Building Blocks
Aryls
2,5-Difluorophenylacetyl chloride
Chemistry
Organic Building Blocks
Aryls
Chlorides Fluorinated Building Blocks Carboxylic Acids Acyl Chlorides Benzene Compounds

[ CAS No. 157033-23-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
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3d Animation Molecule Structure of 157033-23-3
Chemical Structure| 157033-23-3
Chemical Structure| 157033-23-3
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Quality Control of [ 157033-23-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 157033-23-3 ]

SDS Specification
Alternatived Products of [ 157033-23-3 ]

Product Details of [ 157033-23-3 ]

CAS No. :157033-23-3 MDL No. :MFCD03424719
Formula : C8H5ClF2O Boiling Point : -
Linear Structure Formula :- InChI Key :LQGHDMOEOHWRGX-UHFFFAOYSA-N
M.W : 190.57 Pubchem ID :2758320
Synonyms :

Calculated chemistry of [ 157033-23-3 ]

Physicochemical Properties

Num. heavy atoms : 12
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.12
Num. rotatable bonds : 2
Num. H-bond acceptors : 3.0
Num. H-bond donors : 0.0
Molar Refractivity : 41.13
TPSA : 17.07 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.64 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.01
Log Po/w (XLOGP3) : 2.57
Log Po/w (WLOGP) : 3.11
Log Po/w (MLOGP) : 2.94
Log Po/w (SILICOS-IT) : 3.51
Consensus Log Po/w : 2.83

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.88
Solubility : 0.252 mg/ml ; 0.00132 mol/l
Class : Soluble
Log S (Ali) : -2.58
Solubility : 0.505 mg/ml ; 0.00265 mol/l
Class : Soluble
Log S (SILICOS-IT) : -3.93
Solubility : 0.0225 mg/ml ; 0.000118 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.68

Safety of [ 157033-23-3 ]

Signal Word:Danger Class:8
Precautionary Statements:P280-P301+P312+P330-P305+P351+P338+P310 UN#:1760
Hazard Statements:H302-H318 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 157033-23-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 157033-23-3 ]

[ 157033-23-3 ] Synthesis Path-Downstream   1~24

  • 1
  • [ 157033-23-3 ]
  • [ 2033-24-1 ]
  • [ 764667-66-5 ]
YieldReaction ConditionsOperation in experiment
4.3 kg With 2,4,6-trimethyl-pyridine In dichloromethane at -5 - 0℃; for 3h;
Reference： [1]Angelaud, Remy; Zhong, Yong-Li; Maligres, Peter; Lee, Jaemoon; Askin, David [Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1949 - 1952]
  • 2
  • [ 85068-27-5 ]
  • [ 157033-23-3 ]
YieldReaction ConditionsOperation in experiment
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 25 - 30℃; for 3.5h;
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 24h; 4.1.5 General procedure for library synthesis General procedure: To the various carboxylic acids (obtained from ASDI, Inc., 0.076 mmol, 1 equiv.) was added dry DCM (0.5 mL), oxalyl chloride (0.076 mmol, 1 equiv.), and then 2 drops of DMF. The reactions were placed in the shaker and reacted overnight at ambient temperature for 24 h. A solution of the hydrochloride salt of 3 (0.048 mmol, 1 equiv.) in 1.5 mL of DMF was added, followed by DIEA (0.240 mmol, 5 equiv.). The vials were agitated in the shaker for 24 h at ambient temperature. The solvent was removed in a Genevac HT24 centrifugal evaporator, and the crude intermediates were carried forward without purification. To each of the above crude products was added 10% TEA in MeOH (2 mL). The reaction vials were then placed in the shaker at 33 °C overnight, and the solvent was evaporated. All the crude products were purified via preparative HPLC to >95% purity, and the desired products in the yields as described below.
With thionyl chloride In chloroform at 80℃; 75 INTERMEDIATE 75 - PREPARATION OF (Z)-Ethyl 2-amino-2-(2-(2,5- difluorophenyl)acetoxyimino)acetate.; 2-(2,5-difluorophenyl)acetyl chloride was prepared by heating overnight a suspension of 2,5-difluorophenylacetic acid (0.865 g; 3.67 mmol) and thionyl chloride (1.34 ml 18.15 mmol) in chloroform (30 mL) at 80 0C. After evaporation of the solvent and the excess of the thionyl chloride under reduced pressure, the residue was dissolved in dried dichloromethane (10 mL). This solution was added to a suspension of (Z)-ethyl 2-amino-2- (hydroxyimino)acetate (0.500 g; 3.67 mmol) and Λ/,Λ/-diisopropylethylamine (1.03 mL; 5.87 mmol) in dry dichloromethane (20 mL) cooled at -10 0C and stirred for 10 minutes. The mixture was stirred at room temperature for 23 h and poured into a mixture of ice/water. The white precipitate is filtered off and washed with dichloromethane and dried under reduced pressure to afford 0.469 g (45%) of (Z)-ethyl 2-amino-2-(2-(2,5- difluorophenyl)acetoxyimino)acetate as a white solid. ESI/APCI (+) : 287 (M+H), 309 (M+Na). ESIAPCK-) : 285 (M-H).
With thionyl chloride In toluene at 80℃; Inert atmosphere;

Reference： [1]Angelaud, Remy; Zhong, Yong-Li; Maligres, Peter; Lee, Jaemoon; Askin, David [Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1949 - 1952]
[2]Ochiana, Stefan O.; Pandarinath, Vidya; Wang, Zhouxi; Kapoor, Rishika; Ondrechen, Mary Jo; Ruben, Larry; Pollastri, Michael P. [European Journal of Medicinal Chemistry, 2013, vol. 62, p. 777 - 784]
[3]Current Patent Assignee: REMYND; KATHOLIEKE UNIVERSITEIT LEUVEN - WO2010/142801, 2010, A1 Location in patent: Page/Page column 170
[4]Dziuk, Błażej; Kafarski, Paweł; Pirat, Jean-Luc; Talma, Michał; Wanat, Weronika [Biomolecules, 2020, vol. 10, # 4]
  • 3
  • [ 157033-23-3 ]
  • [ 767352-24-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 4.3 kg / 2,4,6-collidine / CH2Cl2 / 3 h / -5 - 0 °C 2: 2.5 h / Heating
Reference： [1]Angelaud, Remy; Zhong, Yong-Li; Maligres, Peter; Lee, Jaemoon; Askin, David [Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1949 - 1952]
  • 4
  • [ 157033-23-3 ]
  • [ 848667-50-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 4.3 kg / 2,4,6-collidine / CH2Cl2 / 3 h / -5 - 0 °C 2: 2.5 h / Heating 3: HCl; H2 / (S)-BINAP-RuCl2 / methanol / 60 °C / 7757.22 Torr
Reference： [1]Angelaud, Remy; Zhong, Yong-Li; Maligres, Peter; Lee, Jaemoon; Askin, David [Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1949 - 1952]
  • 5
  • [ 157033-23-3 ]
  • (R)-4-(2,5-Difluoro-phenyl)-3-hydroxy-butyric acid methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 4.3 kg / 2,4,6-collidine / CH2Cl2 / 3 h / -5 - 0 °C 2: 2.5 h / Heating 3: HCl; H2 / (S)-BINAP-RuCl2 / methanol / 60 °C / 7757.22 Torr
Reference： [1]Angelaud, Remy; Zhong, Yong-Li; Maligres, Peter; Lee, Jaemoon; Askin, David [Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1949 - 1952]
  • 6
  • [ 157033-23-3 ]
  • [ 848667-53-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: 4.3 kg / 2,4,6-collidine / CH2Cl2 / 3 h / -5 - 0 °C 2.1: 2.5 h / Heating 3.1: HCl; H2 / (S)-BINAP-RuCl2 / methanol / 60 °C / 7757.22 Torr 3.2: LiOH / tetrahydrofuran / 0.5 h / 20 - 25 °C 3.3: EDC*HCl; aq.HCl / H2O / 1 h / 20 - 22 °C 4.1: 78 percent / triphenylphosphine; diisopropyl azodicarboxylate / toluene / 2 h / 20 - 30 °C 5.1: methanol / 0.17 h / 20 °C 5.2: H2 / Pd/C / methanol / 1 h / 20 °C / 2068.59 Torr
Reference： [1]Angelaud, Remy; Zhong, Yong-Li; Maligres, Peter; Lee, Jaemoon; Askin, David [Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1949 - 1952]
  • 7
  • [ 157033-23-3 ]
  • [ 848667-51-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: 4.3 kg / 2,4,6-collidine / CH2Cl2 / 3 h / -5 - 0 °C 2.1: 2.5 h / Heating 3.1: HCl; H2 / (S)-BINAP-RuCl2 / methanol / 60 °C / 7757.22 Torr 3.2: LiOH / tetrahydrofuran / 0.5 h / 20 - 25 °C
Reference： [1]Angelaud, Remy; Zhong, Yong-Li; Maligres, Peter; Lee, Jaemoon; Askin, David [Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1949 - 1952]
  • 8
  • [ 157033-23-3 ]
  • (R)-4-(2,5-Difluoro-phenyl)-3-hydroxy-butyric acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: 4.3 kg / 2,4,6-collidine / CH2Cl2 / 3 h / -5 - 0 °C 2.1: 2.5 h / Heating 3.1: HCl; H2 / (S)-BINAP-RuCl2 / methanol / 60 °C / 7757.22 Torr 3.2: LiOH / tetrahydrofuran / 0.5 h / 20 - 25 °C
Reference： [1]Angelaud, Remy; Zhong, Yong-Li; Maligres, Peter; Lee, Jaemoon; Askin, David [Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1949 - 1952]
  • 9
  • [ 157033-23-3 ]
  • [ 767352-26-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: 4.3 kg / 2,4,6-collidine / CH2Cl2 / 3 h / -5 - 0 °C 2.1: 2.5 h / Heating 3.1: HCl; H2 / (S)-BINAP-RuCl2 / methanol / 60 °C / 7757.22 Torr 3.2: LiOH / tetrahydrofuran / 0.5 h / 20 - 25 °C 3.3: EDC*HCl; aq.HCl / H2O / 1 h / 20 - 22 °C 4.1: 78 percent / triphenylphosphine; diisopropyl azodicarboxylate / toluene / 2 h / 20 - 30 °C
Reference： [1]Angelaud, Remy; Zhong, Yong-Li; Maligres, Peter; Lee, Jaemoon; Askin, David [Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1949 - 1952]
  • 10
  • [ 157033-23-3 ]
  • [ 767352-25-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: 4.3 kg / 2,4,6-collidine / CH2Cl2 / 3 h / -5 - 0 °C 2.1: 2.5 h / Heating 3.1: HCl; H2 / (S)-BINAP-RuCl2 / methanol / 60 °C / 7757.22 Torr 3.2: LiOH / tetrahydrofuran / 0.5 h / 20 - 25 °C 3.3: EDC*HCl; aq.HCl / H2O / 1 h / 20 - 22 °C
Reference： [1]Angelaud, Remy; Zhong, Yong-Li; Maligres, Peter; Lee, Jaemoon; Askin, David [Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1949 - 1952]
  • 11
  • [ 157033-23-3 ]
  • N-benzyloxy-4-(2,5-difluorophenyl)-3(R)-hydroxybutanamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: 4.3 kg / 2,4,6-collidine / CH2Cl2 / 3 h / -5 - 0 °C 2.1: 2.5 h / Heating 3.1: HCl; H2 / (S)-BINAP-RuCl2 / methanol / 60 °C / 7757.22 Torr 3.2: LiOH / tetrahydrofuran / 0.5 h / 20 - 25 °C 3.3: EDC*HCl; aq.HCl / H2O / 1 h / 20 - 22 °C
Reference： [1]Angelaud, Remy; Zhong, Yong-Li; Maligres, Peter; Lee, Jaemoon; Askin, David [Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1949 - 1952]
  • 12
  • [ 157033-23-3 ]
  • [ 486459-98-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: 4.3 kg / 2,4,6-collidine / CH2Cl2 / 3 h / -5 - 0 °C 2.1: 2.5 h / Heating 3.1: HCl; H2 / (S)-BINAP-RuCl2 / methanol / 60 °C / 7757.22 Torr 3.2: LiOH / tetrahydrofuran / 0.5 h / 20 - 25 °C 3.3: EDC*HCl; aq.HCl / H2O / 1 h / 20 - 22 °C 4.1: 78 percent / triphenylphosphine; diisopropyl azodicarboxylate / toluene / 2 h / 20 - 30 °C 5.1: methanol / 0.17 h / 20 °C 5.2: H2 / Pd/C / methanol / 1 h / 20 °C / 2068.59 Torr 6.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C 6.2: 0.46 g / LiOH*H2O / tetrahydrofuran / 20 °C
Reference： [1]Angelaud, Remy; Zhong, Yong-Li; Maligres, Peter; Lee, Jaemoon; Askin, David [Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1949 - 1952]
  • 13
  • [ 157033-23-3 ]
  • C9H17NO3 [ No CAS ]
  • C17H21F2NO4 [ No CAS ]
Reference： [1]Current Patent Assignee: BAYER AG - US6359151, 2002, B2 Location in patent: Page column 69
  • 14
  • [ 157033-23-3 ]
  • [ 957194-13-7 ]
  • 2-(2,5-difluorophenyl)-1-(7-iodo-1,2,3,4-tetrahydro-pyrido[2,3-b]pyrazin-1-yl)-ethanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
14% With pyridine In tetrahydrofuran at 0 - 20℃;
Reference： [1]Location in patent: experimental part Milkiewicz, Karen L.; Weinberg, Linda R.; Albom, Mark S.; Angeles, Thelma S.; Cheng, Mangeng; Ghose, Arup K.; Roemmele, Renee C.; Theroff, Jay P.; Underiner, Ted L.; Zificsak, Craig A.; Dorsey, Bruce D. [Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 12, p. 4351 - 4362]
  • 15
  • [ 157033-23-3 ]
  • [ 10489-74-4 ]
  • [ 1258517-58-6 ]
YieldReaction ConditionsOperation in experiment
45% With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -10 - 20℃; for 22.5h; INTERMEDIATE 75 - PREPARATION OF (Z)-Ethyl 2-amino-2-(2-(2,5- difluorophenyl)acetoxyimino)acetate.; 2-(2,5-difluorophenyl)acetyl chloride was prepared by heating overnight a suspension of 2,5-difluorophenylacetic acid (0.865 g; 3.67 mmol) and thionyl chloride (1.34 ml 18.15 mmol) in chloroform (30 mL) at 80 0C. After evaporation of the solvent and the excess of the thionyl chloride under reduced pressure, the residue was dissolved in dried dichloromethane (10 mL). This solution was added to a suspension of (Z)-ethyl 2-amino-2- (hydroxyimino)acetate (0.500 g; 3.67 mmol) and Lambda/,Lambda/-diisopropylethylamine (1.03 mL; 5.87 mmol) in dry dichloromethane (20 mL) cooled at -10 0C and stirred for 10 minutes. The mixture was stirred at room temperature for 23 h and poured into a mixture of ice/water. The white precipitate is filtered off and washed with dichloromethane and dried under reduced pressure to afford 0.469 g (45%) of (Z)-ethyl 2-amino-2-(2-(2,5- difluorophenyl)acetoxyimino)acetate as a white solid. ESI/APCI (+) : 287 (M+H), 309 (M+Na). ESIAPCK-) : 285 (M-H).
Reference： [1]Patent: WO2010/142801,2010,A1 .Location in patent: Page/Page column 170
  • 16
  • [ 157033-23-3 ]
  • [ 1258503-82-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 22.5 h / -10 - 20 °C 2.1: pyridine / 2 h / 120 °C 3.1: ethanol; sodium hydroxide / 1 h / 20 °C 3.2: pH 1
Reference： [1]Current Patent Assignee: REMYND; KATHOLIEKE UNIVERSITEIT LEUVEN - WO2010/142801, 2010, A1
  • 17
  • [ 157033-23-3 ]
  • [ 1258503-81-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / 22.5 h / -10 - 20 °C 2: pyridine / 2 h / 120 °C
Reference： [1]Current Patent Assignee: REMYND; KATHOLIEKE UNIVERSITEIT LEUVEN - WO2010/142801, 2010, A1
  • 18
  • [ 157033-23-3 ]
  • [ 122-52-1 ]
  • C12H16F2NO4P [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: 2,5-difluorophenyl acetyl chloride; triethyl phosphite In diethyl ether at 0℃; Inert atmosphere; Stage #2: With pyridine; hydroxylamine hydrochloride In ethanol at 20℃; Inert atmosphere;
Reference： [1]Dziuk, Błażej; Kafarski, Paweł; Pirat, Jean-Luc; Talma, Michał; Wanat, Weronika [Biomolecules, 2020, vol. 10, # 4]
  • 19
  • [ 157033-23-3 ]
  • [ 122-52-1 ]
  • C12H15F2O4P [ No CAS ]
YieldReaction ConditionsOperation in experiment
In diethyl ether at 0℃; Inert atmosphere;
Reference： [1]Dziuk, Błażej; Kafarski, Paweł; Pirat, Jean-Luc; Talma, Michał; Wanat, Weronika [Biomolecules, 2020, vol. 10, # 4]
  • 20
  • [ 157033-23-3 ]
  • C12H18F2NO3P [ No CAS ]
  • C13H18F2NO4P [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: diethyl ether / 0 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: zinc / methanol / 68 °C
Reference： [1]Dziuk, Błażej; Kafarski, Paweł; Pirat, Jean-Luc; Talma, Michał; Wanat, Weronika [Biomolecules, 2020, vol. 10, # 4]
  • 21
  • [ 157033-23-3 ]
  • 1-amino-2-(2,5-difluorophenyl)ethylphosphonic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: diethyl ether / 0 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: ammonium formate; zinc / methanol / 68 °C 2.2: 8 h / Reflux
Reference： [1]Dziuk, Błażej; Kafarski, Paweł; Pirat, Jean-Luc; Talma, Michał; Wanat, Weronika [Biomolecules, 2020, vol. 10, # 4]
  • 22
  • [ 157033-23-3 ]
  • [ 95-50-1 ]
  • 1-(3,4-dichlorophenyl)-2-(2,5-difluorophenyl)ethan-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
4.87 g With aluminum (III) chloride at 0 - 20℃; for 8.5h; Synthesis of 1-(3,4-dichlorophenyl)-2-(2,5-difluorophenyl) ethan-1-one (2a). The intermediate 1a (20mmol) was added into the benzene derivatives (24mmol) at 0 , and the mixture was stirred for 30min, and then the anhydrous AlCl3 (4.00g, 30mmol) was added. The reaction mixture was stirred at room temperature for 8h. Then, the solution mixture was poured into ice water (50mL) and then extracted by ethyl acetate (100mL×3). The organic layer was dried over Na2SO4, and evaporated. The residue was purified by column chromatography on silica gel (eluent: PET/EA=100/1,) to give compounds 2a as yellow solid 4.87g, yield: 80.9%. Mp: 186.3-188.5. 1H NMR (500MHz, DMSO-d6): δ 8.27 (s, 1H), 8.01 (d, J=8.4Hz, 1H), 7.86 (d, J=8.4Hz, 1H), 7.28-7.15 (m, 3H), 4.55 (s, 2H).
Reference： [1]Si, Dongjuan; Luo, Huijuan; Zhang, Xiaomeng; Yang, Kundi; Wen, Hongmei; Li, Wei; Liu, Jian [Bioorganic Chemistry, 2021, vol. 115]
  • 23
  • [ 157033-23-3 ]
  • 3-(4-chlorophenyl)-4-(3,4-dichlorophenyl)-5-(2,5-difluorophenyl)-5-hydroxy-1,5-dihydro-2H-pyrrol-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: aluminum (III) chloride / 8.5 h / 0 - 20 °C 2: bromine / diethyl ether / 2 h / 20 °C / Inert atmosphere 3: aluminum oxide; potassium hydroxide / 1,4-dioxane / 8 h / 60 °C
Reference： [1]Si, Dongjuan; Luo, Huijuan; Zhang, Xiaomeng; Yang, Kundi; Wen, Hongmei; Li, Wei; Liu, Jian [Bioorganic Chemistry, 2021, vol. 115]
  • 24
  • [ 157033-23-3 ]
  • C14H7BrCl2F2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: aluminum (III) chloride / 8.5 h / 0 - 20 °C 2: bromine / diethyl ether / 2 h / 20 °C / Inert atmosphere
Reference： [1]Si, Dongjuan; Luo, Huijuan; Zhang, Xiaomeng; Yang, Kundi; Wen, Hongmei; Li, Wei; Liu, Jian [Bioorganic Chemistry, 2021, vol. 115]

Tags: 157033-23-3 synthesis path| 157033-23-3 SDS| 157033-23-3 COA| 157033-23-3 purity| 157033-23-3 application| 157033-23-3 NMR| 157033-23-3 COA| 157033-23-3 structure

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