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Chemical Structure| 147362-90-1 Chemical Structure| 147362-90-1

Structure of 147362-90-1

Chemical Structure| 147362-90-1

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Product Details of [ 147362-90-1 ]

CAS No. :147362-90-1
Formula : C9H13N3O2
M.W : 195.22
SMILES Code : O=C(OC(C)(C)C)NC1=NN=CC=C1
MDL No. :MFCD24466705

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Application In Synthesis of [ 147362-90-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 147362-90-1 ]

[ 147362-90-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 89203-22-5 ]
  • [ 147362-90-1 ]
YieldReaction ConditionsOperation in experiment
1,1-Dimethylethyl 3-pyridazinylcarbamate To a stirred suspension of <strong>[89203-22-5]3-pyridazinamine hydrochloride</strong> (100 g, 760 mmol) in DCM (1000 ml) TEA (212 ml, 1520 mmol) was added dropwise under argon flow. The mixture was stirred for 10 minutes then DMAP (13.93 g, 114 mmol) was added portion-wise and the resulting mixture was stirred for 5 minutes then Boc2O (194 ml, 836 mmol) was added and the mixture was stirred at room temperature overnight. Water (1000 ml) and DCM (500 ml) were added, phases were separated and the organic phase was washed with H2O/saturated NH4Cl solution (1/1) (2*1.5 l).The organic phase was filtered, washed with H2O (500 ml) and dried over Na2SO4. Solvent was removed and the resulting crude was purified by flash chromatography eluding with 100% EtOAc to afford the title compound (113 g). 1H NMR (400 MHz, CDCl3): delta 8.88 (dd, 1H), 8.24 (d, 1H), 7.79 (br s, 1H), 7.44 (dd, 1H), 1.55 (s, 9H).
 

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