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Chemical Structure| 1463055-84-6 Chemical Structure| 1463055-84-6

Structure of 1463055-84-6

Chemical Structure| 1463055-84-6

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Product Details of [ 1463055-84-6 ]

CAS No. :1463055-84-6
Formula : C14H16BN3O2
M.W : 269.11
SMILES Code : N#CC1=NNC2=C1C=C(B3OC(C)(C)C(C)(C)O3)C=C2
MDL No. :MFCD30802385

Safety of [ 1463055-84-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 1463055-84-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1463055-84-6 ]

[ 1463055-84-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 201227-39-6 ]
  • [ 73183-34-3 ]
  • [ 1463055-84-6 ]
YieldReaction ConditionsOperation in experiment
20.8% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 90℃; for 16h;Inert atmosphere; Step A: 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-indazole-3-carbonitrile [0449] To a mixture of 5-bromo-lH-indazole-3-carbonitrile (475 mg, 2.139 mmol), 1,4- dioxane (15 mL), potassium acetate (735 mg, 7.49 mmol), and bis(pinacolato)diboron (652 mg, 2.57 mmol), was added PdCl2(dppf) (78 mg, 0.107 mmol). The mixture was purged with N2 and then heated at 90C for 16 hours. The mixture was subsequently cooled and purified by column chromatography, eluting with a gradient of MeOH (0-10%) in DCM. The relevant fractions were collected and concentrated to give the title compound as an off-white solid (120 mg, 20.8%).
 

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