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Chemical Structure| 1445651-49-9 Chemical Structure| 1445651-49-9

Structure of 1445651-49-9

Chemical Structure| 1445651-49-9

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Product Details of [ 1445651-49-9 ]

CAS No. :1445651-49-9
Formula : C13H18BF2NO3
M.W : 285.09
SMILES Code : FC(C1=CC(B2OC(C)(C(C)(C)O2)C)=CN=C1OC)F

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Application In Synthesis of [ 1445651-49-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1445651-49-9 ]

[ 1445651-49-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1254123-51-7 ]
  • [ 73183-34-3 ]
  • [ 1445651-49-9 ]
YieldReaction ConditionsOperation in experiment
33% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; In 1,4-dioxane; at 80℃; for 18.0h;Inert atmosphere; Bis-(pinacolato)-diborane (CAS registry 73183-34-3) (160 mg, 0.63 mmol), KOAc (CAS registry 127-08-2) (165 mg, 1 .68 mml) and PdCI2(dppf)-CH2CI2 adduct (CAS registry 72287- 26-4) (34 mg, 0.04 mmol), were placed in a vial which was degassed and backfilled with N2.A solution of 5-bromo-3-difluoromethyl-2-methoxy-pyridine (CAS registry 1254123-51 -7) (100 mg, 0.42 mmol) in dioxane (2.8 ml) was added and the reaction mixture was heated at 80C for 18 h. The mixture was cooled down and EtOAc (3 ml) was added and the mixture was filtered through hyflo. The dark filtrate was concentrated (245 mg as a brown oil) and then diltuted with heptane (3 ml). The dark solid was filtered off and the filtrate was evaporated and purified by flash chromatography on silica gel (cyclohexane / EtOAc 100:00 to 85:15) to afford the title compound as a colorless oil (40 mg, 33% yield). HPLC RtMO1 =1.28 min; ESIMS: 286 [(M+H)+].
 

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