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Chemical Structure| 1443432-56-1 Chemical Structure| 1443432-56-1

Structure of 1443432-56-1

Chemical Structure| 1443432-56-1

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Product Details of [ 1443432-56-1 ]

CAS No. :1443432-56-1
Formula : C10H12F2N2O3S
M.W : 278.28
SMILES Code : O=C(NS(=O)(N(C)C)=O)C1=CC(F)=C(C)C=C1F
MDL No. :MFCD31811271

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Application In Synthesis of [ 1443432-56-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1443432-56-1 ]

[ 1443432-56-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 103877-80-1 ]
  • [ 3984-14-3 ]
  • [ 1443432-56-1 ]
YieldReaction ConditionsOperation in experiment
79% To a suspension of <strong>[103877-80-1]2,5-difluoro-4-methylbenzoic acid</strong> (6.0 g, 3.5 mmol) in 1,2-dichloroethane (100 mL) was added 4-dimethylaminopyridine (10.65 g, 8.7 mmol), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide:hydrochloride (16.65 g, 8.7 mmol) in 1 ,2- dichloroethane (60 mL) and N,N-diisopropylethylamine (15 mL, 8.60 mmol) and the mixture stirred at room temperature for 20 minutes. N,N-Dimethylsulfamide (8.64 g, 6.9 mmol) was added to the solution and the mixture heated at 60C under nitrogen. After 3 hours the mixture was cooled to room temperature and extracted with dichloromethane (100 mL). The extract was washed successively with 2M hydrochloric acid (2 x 300 mL), brine (100 mL), dried over magnesium sulfate, filtered and evaporated to afford an oil (8.40 g) which solidified at room temperature. The crude product was purified by silica gel column chromatography eluting with ethyl acetate/heptane 1 :4 as eluent to afford the title compound (7.17g, 79%) as a white solid. 1 H NMR (400 MHz, CDCI3):5 2.32 (s, 3H), 3.01 (s, 6H), 7.01 (dd, 1 H), 7.65 (dd, 1 H), 8.74 (br s, 1 H). LCMS Rt = 2.10 minutes MS m/z 277 [M-H]"
 

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