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Chemical Structure| 1440965-10-5 Chemical Structure| 1440965-10-5

Structure of 1440965-10-5

Chemical Structure| 1440965-10-5

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Product Details of [ 1440965-10-5 ]

CAS No. :1440965-10-5
Formula : C10H9ClN4
M.W : 220.66
SMILES Code : ClC1=NN=C(C2=CN(C3CC3)N=C2)C=C1
MDL No. :MFCD26142689
InChI Key :HNUJVEWBLUBNRI-UHFFFAOYSA-N
Pubchem ID :71700023

Safety of [ 1440965-10-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 1440965-10-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1440965-10-5 ]

[ 1440965-10-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 141-30-0 ]
  • [ 1151802-22-0 ]
  • [ 1440965-10-5 ]
YieldReaction ConditionsOperation in experiment
407 g With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; water; at 20 - 90℃;Inert atmosphere; 3-Chloro-6-(l-cyclopropy -lH-pyrazol-4-yl)pyridazine To a 100 mL round bottom flask is added the above solid (6.64 g, 28.4 mol), 3,6-dichoropyridazine (8.46 g, 56.8 mmol), Pd(dppf)Cl2 (1.04 g, 1.42 mol) potassium phosphate (18.1 g, 85.2 mmol), water (5 mL), and 1,4-dioxane (50 g) at room temperature under nitrogen. The reaction mixture is stirred at 90 °C overnight. After cooled to 30 °C, water (20 mL) is added. The aqueous phase is isolated and extracted with ethyl acetate (3 X 30 mL). The combined organic phases are concentrated and the residue is purified on a silica gel flash chromatography to provide a yellow solid (4.07 g, 65percent yield). (MS: [M+l] 222)
 

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