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Chemical Structure| 144-68-3 Chemical Structure| 144-68-3

Structure of Zeaxanthin
CAS No.: 144-68-3

Chemical Structure| 144-68-3

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Zeaxanthin, a dihydroxy carotenoid isolated and purified from the fruits of Zea mays L., is one of the two diet-obtained carotenoids present in the macula region of the eye, and has been shown to contain antioxidant and anti-inflammation characteristics.

Synonyms: Anchovyxanthin; Zeaxanthol; beta-Carotene-3,3'-diol

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Product Citations

Product Citations

Chazan, Ariel ; Das, Ishita ; Fujiwara, Takayoshi ; Murakoshi, Shunya ; Rozenberg, Andrey ; Molina-Marquez, Ana , et al.

Abstract: Energy transfer from light-harvesting ketocarotenoids to the light-driven proton pump xanthorhodopsins has been previously demonstrated in two unique cases: an extreme halophilic bacterium and a terrestrial cyanobacterium. Attempts to find carotenoids that bind and transfer energy to abundant rhodopsin proton pumps from marine photoheterotrophs have thus far failed. Here we detected light energy transfer from the widespread hydroxylated carotenoids zeaxanthin and lutein to the retinal moiety of xanthorhodopsins and proteorhodopsins using functional metagenomics combined with chromophore extraction from the environment. The light-harvesting carotenoids transfer up to 42% of the harvested energy in the violet- or blue-light range to the green-light absorbing retinal chromophore. Our data suggest that these antennas may have a substantial effect on rhodopsin phototrophy in the world's lakes, seas and oceans. However, the functional implications of our findings are yet to be discovered.

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Product Details of Zeaxanthin

CAS No. :144-68-3
Formula : C40H56O2
M.W : 568.87
SMILES Code : CC(/C=C/C1=C(C)C[C@@H](O)CC1(C)C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C2=C(C)C[C@@H](O)CC2(C)C
Synonyms :
Anchovyxanthin; Zeaxanthol; beta-Carotene-3,3'-diol
MDL No. :MFCD08435940
InChI Key :JKQXZKUSFCKOGQ-QAYBQHTQSA-N
Pubchem ID :5280899

Safety of Zeaxanthin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00914576 Healthy Not Applicable Completed - Austria ... More >> Department of Clinical Pharmacology, Medical University of Vienna Vienna, Austria, 1090 Less <<
NCT03433885 - Active, not recruiting December 31, 2023 China, Zhejiang ... More >> The eye hospital of Wenzhou Medical University Wenzhou, Zhejiang, China, 325000 Less <<
NCT00732173 Endometrial Cancer Not Applicable Completed - United States, Ohio ... More >> Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106-5065 Less <<
NCT02221089 Imparied Retinal Vascular Reac... More >>tivity Healthy Subjects Less << Not Applicable Completed - Austria ... More >> Department of clinical Pharmacology, Medical University of Vienna Vienna, Austria, 1080 Less <<
NCT02800408 β-cryptoxanthin Bioavailabilit... More >>y From Biofortified Maize in Humans Less << Not Applicable Unknown December 2016 United States, Wisconsin ... More >> University of Wisconsin-Madison Nutritional Sciences Madison, Wisconsin, United States, 53706 Less <<
NCT01653184 Macular Degeneration Not Applicable Completed - United States, New Jersey ... More >> Mid Atlantic Retina- Cherry Hill Cherry Hill, New Jersey, United States, 08002 United States, Pennsylvania Mid Atlantic Retina - Bethlehem Bethlehem, Pennsylvania, United States, 18020 Mid Atlantic Retina- Hungtindon Valley Huntingdon Valley, Pennsylvania, United States, 19006 Mid Atlantic Retina- Wills Eye Institute Philadelphia, Pennsylvania, United States, 19107 Less <<
NCT02264938 Macular Degeneration Not Applicable Completed - -
NCT03702374 Diabetic Retinopathy Phase 3 Recruiting November 1, 2020 Mexico ... More >> Institute of Experimental and Clinical Therapeutics, Recruiting Guadalajara, Jalisco, Mexico, 44340 Contact: Adolfo D. Rodriguez-Carrizalez, PhD    +52 33 10585200 ext 33658    adolfo.rodriguez@academicos.udg.mx    Contact: Cecilia Olvera-Montaño, MD    +52 33 10 58 52 00 ext 33658    ceciliaom.drcrt@gmail.com    Sub-Investigator: Cecilia Olvera-Montaño, MD          Sub-Investigator: José A. Castellanos-González, MSc          Sub-Investigator: Alejandra G Miranda-Díaz, PhD Less <<
NCT00478439 Aging Age-Rel... More >>ated Macular Degeneration Less << Phase 4 Terminated(Study terminated Re... More >>cruitment delay due to equipment malfunction) Less << - United States, Alabama ... More >> UAB School of Optometry Birmingham, Alabama, United States, 35294 Less <<
NCT00963131 Central Serous Chorioretinopat... More >>hy Less << Phase 2 Completed - Thailand ... More >> Department of Ophthalmology, Faculty of medicine, Prince of Songkla university Hat Yai, Songkhla, Thailand, 90110 Less <<
NCT02679794 Menopause Not Applicable Completed - United States, Indiana ... More >> Purdue Clinical Research Center West Lafayette, Indiana, United States, 47907 Less <<
NCT03326401 - Completed - Turkey ... More >> Hacettepe University Hospital Department of Ophthalmology Polyclinic Ankara, Altındağ, Turkey, 06230 Less <<
NCT00494325 - Completed - Switzerland ... More >> Klinik und Poliklinik für Augenheilkunde, University Bern Bern, Switzerland Less <<
NCT00902408 Age Related Macular Degenerati... More >>on Less << Not Applicable Completed - Netherlands ... More >> University Eye Clinic Maastrich Maastricht, Limburg, Netherlands, 6202AZ Less <<
NCT01142960 Lens Opacity Not Applicable Completed - Hong Kong ... More >> The Hong Kong Polytechnic University Hung Hom, Kowloon, Hong Kong, 0000 Less <<
NCT01951313 Will Consuming Eggs With a Mix... More >>ed Vegetable Salad Increase Carotenoid Absorption Less << Not Applicable Completed - United States, Indiana ... More >> Purdue University West Lafayette, Indiana, United States, 47907 Less <<
NCT01364311 Dry Eye Syndromes Not Applicable Withdrawn - Austria ... More >> Department of Clinical Pharmacology, Medical University Vienna Vienna, Austria, 1090 Less <<
NCT01646047 Diabetes Mellitus - Type 1 ... More >> Diabetes Mellitus - Type 2 Non-proliferative Diabetic Retinopathy Less << Not Applicable Completed - United States, Washington ... More >> Chous Eye Care Associates Tacoma, Washington, United States, 98466 Less <<
NCT01830608 - Withdrawn(Could not find a Spo... More >>nsor for the study) Less << - Austria ... More >> Medical University of Vienna Vienna, Austria, 1090 Less <<
NCT02205632 High Myopia Not Applicable Completed - France ... More >> ophthalmology department, Poitiers University Hospital Poitiers, Vienne, France, 86021 Less <<
NCT00636350 Healthy Phase 1 Completed - United States, Massachusetts ... More >> Tufts University Boston, Massachusetts, United States, 02111 Less <<
NCT01620567 Mild Cognitive Impairment Early Phase 1 Unknown May 2014 United States, Massachusetts ... More >> Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Recruiting Boston, Massachusetts, United States, 02111 Contact: Elizabeth J Johnson, Ph.D.    617-556-3204       Contact: Rohini Vishwanathan, Ph.D.    978 837 2061    rohini.vishwanathan@tufts.edu Less <<
NCT02062034 Non-proliferative Diabetic Ret... More >>inopathy Diabetes Mellitus Type 2 Less << Phase 2 Completed - Mexico ... More >> Cardiovascular Research Unit, University of Guadalajara Guadalajara, Jalisco, Mexico, 44340 Less <<
NCT00718653 Eye Health Not Applicable Completed - United States, Massachusetts ... More >> Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University Boston, Massachusetts, United States, 02111 Less <<
NCT00993330 - Terminated - Austria ... More >> Department of Clinical Pharmacology, Medical University of Vienna Vienna, Austria, 1090 Less <<
NCT00879671 Age-Related Macular Degenerati... More >>on Less << Not Applicable Completed - Austria ... More >> Department of Clinical Pharmacology, Medical University of Vienna Vienna, Austria Less <<
NCT01621646 Mild Cognitive Impairment Not Applicable Completed - United States, Massachusetts ... More >> Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Boston, Massachusetts, United States, 02111 Less <<
NCT01400763 Macular Pigment Not Applicable Completed - -
NCT01534533 Carotid Atherosclerosis ... More >> Carotid Intimal Medial Thickness 1 Less << Phase 2 Phase 3 Completed - China ... More >> Haidian District Beijing, China, 100191 Less <<
NCT01534533 - Completed - -
NCT03068377 Ocular Blood Flow Not Applicable Completed - United States, Indiana ... More >> Glaucoma Research and Diagnostic Center Eugene and Marilyn Glick Eye Institute Indiana University School of Medicine Indianapolis, Indiana, United States, 46202 Less <<
NCT01694680 Age-related Macular Degenerati... More >>on (AMD) Less << Not Applicable Completed - United States, Massachusetts ... More >> TUFTS University Boston, Massachusetts, United States Germany Universitäts Augenklinik - Bonn Bonn, Germany Netherlands Radboud University Hospital Nijmegen, Netherlands, 6525EX United Kingdom Manchester Royal Eye Hospital - Manchester Manchester, United Kingdom Less <<
NCT01269697 Persons Issued From Amd Parent... More >>s Less << Phase 3 Completed - France ... More >> Unité Médicale Rétine Neuro-Ophtalmologie - Service d'Ophtalmologie - Hopital Pellegrin Bordeaux, France, 33076 Service Ophtalmologie - Hôpital général CHU de Dijon Dijon, France, 21000 Less <<
NCT02287298 - Completed - United States, Missouri ... More >> The Retina Center St Louis, Missouri, United States, 63141 Less <<
NCT01859390 - Completed - -
NCT00672230 Lactation Not Applicable Unknown August 2009 United States, Oregon ... More >> Oregon Health and Science University Recruiting Portland, Oregon, United States, 97239-3098 Contact: Sonja L Connor, MS    503-494-7775    connors@ohsu.edu    Contact: William E Connor, MD    503-494-2001    connorw@ohsu.edu Less <<
NCT01480700 Age-related Macular Degenerati... More >>on Less << Not Applicable Completed - France ... More >> Institut Pasteur de Lille Lille, France, 59000 Less <<
NCT01778231 Healthy Not Applicable Unknown May 2013 United Kingdom ... More >> Centre for Public Health Recruiting Belfast, Antrim, United Kingdom, BT126BA Contact: Estelle Lowry, MSc    +44 (0)28 9063 2636    e.lowry05@qub.ac.uk    Sub-Investigator: Estelle Lowry, MSc          Principal Investigator: Ruth Hogg, PhD          Sub-Investigator: Jayne Woodside, PhD Less <<
NCT01859390 Cystic Fibrosis Phase 2 Completed - United States, Arizona ... More >> University Medical Center Tucson, Arizona, United States, 85724 United States, Colorado Children's Hospital Colorado Aurora, Colorado, United States, 80045 United States, Florida The Nemours Children's Clinic Orlando, Florida, United States, 32806 United States, Michigan Children's Hospital of Michigan Detroit, Michigan, United States, 48201 United States, Minnesota University of Minnesota Children's Hospital Minneapolis, Minnesota, United States, 55455 United States, New York Women and Children's Hospital of Buffalo Buffalo, New York, United States, 14222 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 Rainbow Babies and Children's Hospital Cleveland, Ohio, United States, 44106 Nationwide Children's Hospital Columbus, Ohio, United States, 43205 United States, Pennsylvania Penn State Milton S. Hershey Medical Center Hershey, Pennsylvania, United States, 17033 Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania, United States, 15224 United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232-5735 United States, Texas The University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 75390 United States, Wisconsin University of Wisconsin Hospital Center Madison, Wisconsin, United States, 53792 Children's Hospital of Wisconsin Milwaukee, Wisconsin, United States, 53226 Less <<
NCT00596024 Alzheimer's Disease Phase 2 Unknown - United States, Oregon ... More >> Oregon Health and Science University Recruiting Portland, Oregon, United States, 97239 Contact: Wei Wang, PhD    503-418-2423    wangwe@ohsu.edu    Contact: Joseph Quinn, MD    503-494-6976       Principal Investigator: Wei Wang, PhD Less <<
NCT00527553 Age-related Macular Degenerati... More >>on Less << Not Applicable Completed - Netherlands ... More >> University Hostpital Maastricht Maastricht, Netherlands, 6202AZ Less <<
NCT01316198 Age-Related Macular Degenerati... More >>on Less << Not Applicable Completed - Germany ... More >> Friedrich Schiller University Jena, Thuringia, Germany, 07743 Less <<
NCT00909090 Glare Disability in Healthy Su... More >>bjects Less << Phase 2 Phase 3 Unknown December 2011 United States, Georgia ... More >> Vision Sciences Laboratory, UGA Athens, Georgia, United States, 30602 Less <<
NCT01354093 - Completed - United States, Utah ... More >> Moran Eye Center, University of Utah Salt Lake City, Utah, United States, 84132 Less <<
NCT03750968 Nutrient Deficiency ... More >> Pregnancy Related Less << Phase 2 Not yet recruiting December 31, 2022 United States, Utah ... More >> University of Utah John A. Moran Eye Center Not yet recruiting Salt Lake City, Utah, United States, 84132 Contact: Paul S Bernstein, MD, PhD Less <<
NCT02136303 Changes in Macular Pigment Opt... More >>ical Density Less << Not Applicable Recruiting December 2020 Germany ... More >> University Eye Hospital, Friedrich Schiller University Jena Recruiting Jena, Germany, 07743 Less <<
NCT00121589 Macular Degeneration Phase 1 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT00568828 - Unknown February 2008 Germany ... More >> Dep. of Ophthalmology, St. Franziskus Hospital Recruiting Muenster, Germany, 48145 Contact: Meike Zeimer, MD    49-251-933080    kpl-auge@muenster.de Less <<
NCT01404845 Exudative Age-related Macular ... More >>Degeneration Less << Not Applicable Completed - France ... More >> Docteur Jean-Jacques Masella Grenoble, France, 38000 Centre ophtalmologique Rabelais Lyon, France, 69003 Less <<
NCT01527435 - Completed - United States, Missouri ... More >> The Retina Center St. Louis, Missouri, United States, 63141 Less <<
NCT00345176 Age-related Macular Degenerati... More >>on Cataract Less << Phase 3 Completed - -
NCT02113254 Age Macular Degeneration Not Applicable Completed - France ... More >> CHU de Bordeaux Bordeaux, France, 33000 Less <<
NCT03340103 Antioxidant Role of the Lutein... More >> in Preterm Newborn Less << Not Applicable Recruiting October 1, 2018 Italy ... More >> Azienda Ospedaliera di Rilievo Nazionale Santobono-Pausilipon Recruiting Napoli, Italia, Italy, 80100 Contact: Giuseppe De Bernardo, M.D.    +393357441303    pinodebtin@gmail.com    Contact: Desiree Sordino, M.D.    +393383482584    dsordino@gmail.com    Principal Investigator: Giuseppe De Bernardo, M.D.          Azienda Ospedaliera Universitaria Padova Recruiting Padova, Italia, Italy, 35128 Contact: Daniele Trevisanuto, Prof.    +393406632734    daniele.trevisanuto@gmail.com    Sub-Investigator: Daniele Trevisanuto, Prof.          Azienda Ospedaliera Le Scotte Siena Recruiting Siena, Italia, Italy, 53100 Contact: Giuseppe Buonocore, Prof.    +393491770396    buonocore@unisi.it    Sub-Investigator: Giuseppe Buonocore, Prof.          Sub-Investigator: Mariangela Longini, Dr. Less <<
NCT00345176 - Completed - -
NCT01048476 Age-related Macular Degenerati... More >>on Less << Phase 1 Phase 2 Unknown October 2012 China, Beijing ... More >> Peking university Recruiting Beijing, Beijing, China, 100191 Contact: le Ma, MD       male@bjmu.edu.cn Less <<
NCT01528605 Age-related Macular Degenerati... More >>on Less << Not Applicable Completed - China, Beijing ... More >> Haidian District Beijing, Beijing, China, 100191 Less <<
NCT02023645 Mild Cognitive Impairment Not Applicable Unknown December 2015 United States, Georgia ... More >> The University of Georgia Athens, Georgia, United States, 30602 Less <<
NCT01648660 Age Related Maculopathy Not Applicable Completed - -
NCT00564902 - Completed - -
NCT00763659 Age Related Maculopathy Not Applicable Completed - Germany ... More >> Department of Ophthalmology, University Hospital Jena, Germany, 07743 Less <<
NCT02200263 Ocular Albinism (OA) ... More >> Oculocutaneous Albinism (OCA) Less << Not Applicable Recruiting December 2018 United States, Maryland ... More >> Wilmer Eye Institute Recruiting Baltimore, Maryland, United States, 21287-9277 Contact: Mary E. Frey    443-287-7912    mfrey3@jhmi.edu    Sub-Investigator: Mary Frey          Principal Investigator: Neil Bressler, MD Less <<
NCT01621789 Cataract Phase 3 Completed - Brazil ... More >> Dept. of Ophthalmology - UNIFESP/Hospital São Paulo São Paulo, SP, Brazil, 04023-062 Less <<
NCT02017418 Behavior and Behavior Mechanis... More >>ms Less << Not Applicable Completed - United States, Georgia ... More >> Department of Psychology, UGA Athens, Georgia, United States, 30602 Less <<
NCT00564902 Age Related Macular Degenerati... More >>on Cognition Disorders Less << Not Applicable Completed - United States, Illinois ... More >> North Chicago VA Medical Center North Chicago, Illinois, United States, 60064 Less <<
NCT01627977 Epiretinal Membrane ... More >> Macular Hole Proliferative Diabetic Retinopathy Less << Phase 3 Completed - Brazil ... More >> Depto. of Ophthalmology - Hospital São Paulo - UNIFESP São Paulo, SP, Brazil, 04023-062 Less <<
NCT01528605 - Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.79mL

1.76mL

0.88mL

17.58mL

3.52mL

1.76mL

References

 

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