Structure of Zeaxanthin
CAS No.: 144-68-3
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Zeaxanthin, a dihydroxy carotenoid isolated and purified from the fruits of Zea mays L., is one of the two diet-obtained carotenoids present in the macula region of the eye, and has been shown to contain antioxidant and anti-inflammation characteristics.
Synonyms: Anchovyxanthin; Zeaxanthol; beta-Carotene-3,3'-diol
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Phototrophy by antenna-containing rhodopsin pumps in aquatic environments
Chazan, Ariel ; Das, Ishita ; Fujiwara, Takayoshi ; Murakoshi, Shunya ; Rozenberg, Andrey ; Molina-Marquez, Ana , et al.
Abstract: Energy transfer from light-harvesting ketocarotenoids to the light-driven proton pump xanthorhodopsins has been previously demonstrated in two unique cases: an extreme halophilic bacterium and a terrestrial cyanobacterium. Attempts to find carotenoids that bind and transfer energy to abundant rhodopsin proton pumps from marine photoheterotrophs have thus far failed. Here we detected light energy transfer from the widespread hydroxylated carotenoids zeaxanthin and lutein to the retinal moiety of xanthorhodopsins and proteorhodopsins using functional metagenomics combined with chromophore extraction from the environment. The light-harvesting carotenoids transfer up to 42% of the harvested energy in the violet- or blue-light range to the green-light absorbing retinal chromophore. Our data suggest that these antennas may have a substantial effect on rhodopsin phototrophy in the world's lakes, seas and oceans. However, the functional implications of our findings are yet to be discovered.
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CAS No. : | 144-68-3 |
Formula : | C40H56O2 |
M.W : | 568.87 |
SMILES Code : | CC(/C=C/C1=C(C)C[C@@H](O)CC1(C)C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C2=C(C)C[C@@H](O)CC2(C)C |
Synonyms : |
Anchovyxanthin; Zeaxanthol; beta-Carotene-3,3'-diol
|
MDL No. : | MFCD08435940 |
InChI Key : | JKQXZKUSFCKOGQ-QAYBQHTQSA-N |
Pubchem ID : | 5280899 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H332-H335 |
Precautionary Statements: | P261-P280-P305+P351+P338 |
Clinical Trial:
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NCT00914576 | Healthy | Not Applicable | Completed | - | Austria ... More >> Department of Clinical Pharmacology, Medical University of Vienna Vienna, Austria, 1090 Less << |
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NCT00732173 | Endometrial Cancer | Not Applicable | Completed | - | United States, Ohio ... More >> Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106-5065 Less << |
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NCT02800408 | β-cryptoxanthin Bioavailabilit... More >>y From Biofortified Maize in Humans Less << | Not Applicable | Unknown | December 2016 | United States, Wisconsin ... More >> University of Wisconsin-Madison Nutritional Sciences Madison, Wisconsin, United States, 53706 Less << |
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NCT02264938 | Macular Degeneration | Not Applicable | Completed | - | - |
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NCT00478439 | Aging Age-Rel... More >>ated Macular Degeneration Less << | Phase 4 | Terminated(Study terminated Re... More >>cruitment delay due to equipment malfunction) Less << | - | United States, Alabama ... More >> UAB School of Optometry Birmingham, Alabama, United States, 35294 Less << |
NCT00963131 | Central Serous Chorioretinopat... More >>hy Less << | Phase 2 | Completed | - | Thailand ... More >> Department of Ophthalmology, Faculty of medicine, Prince of Songkla university Hat Yai, Songkhla, Thailand, 90110 Less << |
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NCT03326401 | - | Completed | - | Turkey ... More >> Hacettepe University Hospital Department of Ophthalmology Polyclinic Ankara, Altındağ, Turkey, 06230 Less << | |
NCT00494325 | - | Completed | - | Switzerland ... More >> Klinik und Poliklinik für Augenheilkunde, University Bern Bern, Switzerland Less << | |
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NCT01830608 | - | Withdrawn(Could not find a Spo... More >>nsor for the study) Less << | - | Austria ... More >> Medical University of Vienna Vienna, Austria, 1090 Less << | |
NCT02205632 | High Myopia | Not Applicable | Completed | - | France ... More >> ophthalmology department, Poitiers University Hospital Poitiers, Vienne, France, 86021 Less << |
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NCT01859390 | - | Completed | - | - | |
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NCT01778231 | Healthy | Not Applicable | Unknown | May 2013 | United Kingdom ... More >> Centre for Public Health Recruiting Belfast, Antrim, United Kingdom, BT126BA Contact: Estelle Lowry, MSc +44 (0)28 9063 2636 e.lowry05@qub.ac.uk Sub-Investigator: Estelle Lowry, MSc Principal Investigator: Ruth Hogg, PhD Sub-Investigator: Jayne Woodside, PhD Less << |
NCT01859390 | Cystic Fibrosis | Phase 2 | Completed | - | United States, Arizona ... More >> University Medical Center Tucson, Arizona, United States, 85724 United States, Colorado Children's Hospital Colorado Aurora, Colorado, United States, 80045 United States, Florida The Nemours Children's Clinic Orlando, Florida, United States, 32806 United States, Michigan Children's Hospital of Michigan Detroit, Michigan, United States, 48201 United States, Minnesota University of Minnesota Children's Hospital Minneapolis, Minnesota, United States, 55455 United States, New York Women and Children's Hospital of Buffalo Buffalo, New York, United States, 14222 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 Rainbow Babies and Children's Hospital Cleveland, Ohio, United States, 44106 Nationwide Children's Hospital Columbus, Ohio, United States, 43205 United States, Pennsylvania Penn State Milton S. Hershey Medical Center Hershey, Pennsylvania, United States, 17033 Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania, United States, 15224 United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232-5735 United States, Texas The University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 75390 United States, Wisconsin University of Wisconsin Hospital Center Madison, Wisconsin, United States, 53792 Children's Hospital of Wisconsin Milwaukee, Wisconsin, United States, 53226 Less << |
NCT00596024 | Alzheimer's Disease | Phase 2 | Unknown | - | United States, Oregon ... More >> Oregon Health and Science University Recruiting Portland, Oregon, United States, 97239 Contact: Wei Wang, PhD 503-418-2423 wangwe@ohsu.edu Contact: Joseph Quinn, MD 503-494-6976 Principal Investigator: Wei Wang, PhD Less << |
NCT00527553 | Age-related Macular Degenerati... More >>on Less << | Not Applicable | Completed | - | Netherlands ... More >> University Hostpital Maastricht Maastricht, Netherlands, 6202AZ Less << |
NCT01316198 | Age-Related Macular Degenerati... More >>on Less << | Not Applicable | Completed | - | Germany ... More >> Friedrich Schiller University Jena, Thuringia, Germany, 07743 Less << |
NCT00909090 | Glare Disability in Healthy Su... More >>bjects Less << | Phase 2 Phase 3 | Unknown | December 2011 | United States, Georgia ... More >> Vision Sciences Laboratory, UGA Athens, Georgia, United States, 30602 Less << |
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NCT00568828 | - | Unknown | February 2008 | Germany ... More >> Dep. of Ophthalmology, St. Franziskus Hospital Recruiting Muenster, Germany, 48145 Contact: Meike Zeimer, MD 49-251-933080 kpl-auge@muenster.de Less << | |
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NCT02113254 | Age Macular Degeneration | Not Applicable | Completed | - | France ... More >> CHU de Bordeaux Bordeaux, France, 33000 Less << |
NCT03340103 | Antioxidant Role of the Lutein... More >> in Preterm Newborn Less << | Not Applicable | Recruiting | October 1, 2018 | Italy ... More >> Azienda Ospedaliera di Rilievo Nazionale Santobono-Pausilipon Recruiting Napoli, Italia, Italy, 80100 Contact: Giuseppe De Bernardo, M.D. +393357441303 pinodebtin@gmail.com Contact: Desiree Sordino, M.D. +393383482584 dsordino@gmail.com Principal Investigator: Giuseppe De Bernardo, M.D. Azienda Ospedaliera Universitaria Padova Recruiting Padova, Italia, Italy, 35128 Contact: Daniele Trevisanuto, Prof. +393406632734 daniele.trevisanuto@gmail.com Sub-Investigator: Daniele Trevisanuto, Prof. Azienda Ospedaliera Le Scotte Siena Recruiting Siena, Italia, Italy, 53100 Contact: Giuseppe Buonocore, Prof. +393491770396 buonocore@unisi.it Sub-Investigator: Giuseppe Buonocore, Prof. Sub-Investigator: Mariangela Longini, Dr. Less << |
NCT00345176 | - | Completed | - | - | |
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NCT00564902 | - | Completed | - | - | |
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NCT01627977 | Epiretinal Membrane ... More >> Macular Hole Proliferative Diabetic Retinopathy Less << | Phase 3 | Completed | - | Brazil ... More >> Depto. of Ophthalmology - Hospital São Paulo - UNIFESP São Paulo, SP, Brazil, 04023-062 Less << |
NCT01528605 | - | Completed | - | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.76mL 0.35mL 0.18mL |
8.79mL 1.76mL 0.88mL |
17.58mL 3.52mL 1.76mL |