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Structure of 143654-59-5

Chemical Structure| 143654-59-5

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Product Details of [ 143654-59-5 ]

CAS No. :143654-59-5
Formula : C10H11FO2
M.W : 182.19
SMILES Code : O=C(OC)CCC1=CC=CC=C1F
MDL No. :MFCD12031751
InChI Key :LIXJACUBEJXGIC-UHFFFAOYSA-N
Pubchem ID :15479441

Safety of [ 143654-59-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H320-H335
Precautionary Statements:P264-P270-P301+P312-P330

Application In Synthesis of [ 143654-59-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 143654-59-5 ]

[ 143654-59-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 18944-77-9 ]
  • [ 143654-59-5 ]
YieldReaction ConditionsOperation in experiment
100% In a Parr hydrogenation vessel is placed <strong>[18944-77-9]2-fluorocinnamic acid</strong> (1h) (1.0 equiv) and palladium on carbon in a 1/1 methanol/ethyl acetate solution. The heterogeneous solution is placed on a Parr shaker and treated with hydrogen (50 psi) until uptake has ceased. The mixture is filtered through Celite and concentrated under reduced pressure. The residue is taken up in diethyl ether and is treated with diazomethane until the yellow color persists. The solution is concentrated under reduced pressure giving the crude methyl ester. Purification is effected by column chromatography on silica gel (hexane/ethyl acetate 5/1) to yield Methyl 3-(2-fluorophenyl)propionate (1i) in quantitative yield.
 

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