143071-39-0|2-(5-Nitropyridin-2-yloxy)ethanol| Ambeed

Yield	Reaction Conditions	Operation in experiment
91%		Ethylene glycol (0.883 mL, 15.84 mmol) was dissolved in DMF (10 mL) at 0 °C. Sodium hydride (253 mg, 6.33 mmol, 60percent in mineral oil) was added to the reactionmixture portion wise and the reaction mixture was stirred for 10 minutes at 0 °C. Next,<strong>[456-24-6]2-fluoro-5-nitropyridine</strong> (450 mg, 3.17 mmol) dissolved in 1 mL of DMF was added to the reaction mixture which was allowed to stir for 15 minutes at room temperature. The mixture was then quenched with saturated ammonium chloride and extracted with EtOAc (lx). The organic layer was then washed with 10percent aq. LiC1 (3x), brine (lx), dried withsodium sulfate, filtered and concentrated to yield Intermediate I-55A, (530 mg, 2.88 mmol, 91 percent yield), as a clear oil which was was brought forward without further purification. LC-MS: Method H, MS (ESI) m/z: 185.1 (M+H)t ?H NMR (400MHz, CHLOROFORM-d) oe 9.09 (d, J2.9 Hz, 1H), 8.41 (dd, J9.0, 2.9 Hz, 1H), 6.92 (dd, J9.2, 0.4 Hz, 1H), 4.65-4.54 (m, 2H), 4.09-3.96 (m, 2H), 2.32 (t, J=5.9 Hz, 1H).
91%		Ethylene glycol (0.883 mL, 15.84 mmol) was dissolved in DMF (10 mL) at 0 °C.Sodium hydride (253 mg, 6.33 mmol, 60percent in mineral oil) was added to the reaction mixture portion wise and the reaction mixture was stirred for 10 minutes at 0 °C. <strong>[456-24-6]2-fluoro-5-nitropyridine</strong> (450 mg, 3.17 mmol) dissolved in 1 mL of DMF was then added to the reaction mixture which was allowed to stir for 15 minutes at room temperature.The mixture was then quenched with saturated ammonium chloride and extracted with EtOAc (lx). The organic layer was then washed with 10percent aqueous LiC1 (3x), brine (lx), dried with sodium sulfate, filtered and concentrated to yield Intermediate I-93A, (530 mg, 2.88 mmol, 91 percent yield), as a clear oil which was brought forward without further purification. LC-MS: Method H, MS (ESI) m/z: 185.1 (M+H)t ?H NMR(400MHz, CDC13) oe 9.09 (d, J=2.9 Hz, 1H), 8.41 (dd, J9.0, 2.9 Hz, 1H), 6.92 (dd, J=9.2,0.4 Hz, 1H), 4.65-4.54 (m, 2H), 4.09-3.96 (m, 2H), 2.32 (t, J=5.9 Hz, 1H).

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2-(5-Nitropyridin-2-yloxy)ethanol

CAS No.: 143071-39-0

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Product Details of [ 143071-39-0 ]

Safety of [ 143071-39-0 ]

Application In Synthesis of [ 143071-39-0 ]

[ 143071-39-0 ] Synthesis Path-Downstream 1~1

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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
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