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Chemical Structure| 1427587-67-4 Chemical Structure| 1427587-67-4

Structure of 1427587-67-4

Chemical Structure| 1427587-67-4

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Product Details of [ 1427587-67-4 ]

CAS No. :1427587-67-4
Formula : C9H13BrN2O2S
M.W : 293.18
SMILES Code : CCS(=O)(NC(C1=CC(Br)=CN=C1)C)=O
MDL No. :MFCD32875541

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Application In Synthesis of [ 1427587-67-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1427587-67-4 ]

[ 1427587-67-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 113118-81-3 ]
  • [ 1520-70-3 ]
  • [ 75-16-1 ]
  • [ 1427587-67-4 ]
YieldReaction ConditionsOperation in experiment
130 mg To a vial is added 5-bromonicotinaldehyde (300 mg, 1.61 mmol) and <strong>[1520-70-3]ethanesulfonamide</strong> (220 mg, 2.02 mmol) in 6 ml of toluene, followed by the addition of titanium(IV) isopropoxide (1 ml, 3.23 mmol). The reaction mixture is stirred at 120° C. for 6 hours. The reaction mixture is concentrated. The residue is dissolved in 5 ml of THF and is cooled to ?40° C., methylmagnesium bromide, 3M in ether (1.6 ml, 4.84 mmol) is added dropwise. The reaction mixture is warm up and stirred at room temperature for 18 hours. The reaction mixture is diluted with EtOAc, washed with saturated NH4Cl, (aq.) brine, dried over anhydrous Na2SO4, filtered and concentrated to give the crude product. Purification by the flash column chromatography affords 130 mg of ethanesulfonic acid [1-(5-bromo-pyridin-3-yl)-ethyl]-amide.
 

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