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Chemical Structure| 1427371-57-0 Chemical Structure| 1427371-57-0

Structure of 1427371-57-0

Chemical Structure| 1427371-57-0

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Product Details of [ 1427371-57-0 ]

CAS No. :1427371-57-0
Formula : C10H12BrNO2
M.W : 258.11
SMILES Code : O=C(OCC)CCC1=NC=C(Br)C=C1
MDL No. :MFCD23709081

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Application In Synthesis of [ 1427371-57-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1427371-57-0 ]

[ 1427371-57-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 624-28-2 ]
  • [ 6414-69-3 ]
  • [ 1427371-57-0 ]
YieldReaction ConditionsOperation in experiment
B. A solution of Zn metal (18 g, 0.27 mol) in DMF (5 mL) was purged with N2. BrCH2CH2Br (2.0 g, 10 mmol) was added, followed by TMSCl (0.92 g, 8.5 mmol). The resulting mixture was stirred at 90 C. for 30 min, and allowed to cool to rt. A solution of compound 57a (50 g, 0.22 mol) in DMF (150 mL) was added, and the resulting mixture was stirred overnight at rt. Pd(PPh3)2Cl2 (7.4 g, 10 mmol) was added, followed by 2,5-dibromopyridine (50 g, 0.21 mol). The resulting mixture was stirred at 68 C. for 2 h. The reaction was quenched by the addition of saturated NaHCO3 solution (300 mL). The resulting solution was extracted with EtOAc (2*100 mL), and the combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The residue obtained was purified by flash column chromatography on silica gel (EtOAc/petroleum ether (1:2 v/v)) to obtain compound 57b as a yellow oil. Mass Spectrum (LCMS, ESI pos.): Calcd. for C10H12BrNO2: 258.0 (M+H). Found: 258.2.
 

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