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Chemical Structure| 1427172-46-0 Chemical Structure| 1427172-46-0

Structure of 1427172-46-0

Chemical Structure| 1427172-46-0

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Product Details of [ 1427172-46-0 ]

CAS No. :1427172-46-0
Formula : C9H9BrN2O2
M.W : 257.08
SMILES Code : O=C1N(C2=NC=C(Br)C=C2)CCOC1
MDL No. :N/A

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Application In Synthesis of [ 1427172-46-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1427172-46-0 ]

[ 1427172-46-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109-11-5 ]
  • [ 624-28-2 ]
  • [ 1427172-46-0 ]
YieldReaction ConditionsOperation in experiment
64% With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 100℃;Inert atmosphere; Step 1: Preparation of 4-(5-bromopyridin-2-yl)<strong>[109-11-5]morpholin-3-one</strong> (19a) Morpholin-3-one (500 mg, 4.94 mmol) and 2,5-dibromopyridine(1.76 g, 7.42 mmol) were dissolved in toluene, to which was added cesium carbonate (2.42 g, 7.42 mmol). The resulting mixture was flushed with argon for 3 times. Then Pd2(dba)3 (226 mg, 0.247 mmol) and xantphos (171 mg, 0.296 mmol) were added, followed by flushing again with argon. The reaction mixture was heated to 100 C and allowed to react overnight. After the reaction completed, the mixture was filtered. Column chromatography afforded 815 mg of white solid (compound 19a), yield 64%. m.p.: 119-120 C. 1H NMR (300 MHz, DMSO) δ 8.65 - 8.40 (m, 1H), 8.17 - 7.97 (m, 2H), 4.26 (s, 2H), 4.01 - 3.95 (m, 2H), 3.95 - 3.89 (m, 2H). MS(EI) m/z: 256(M+).
 

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