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Chemical Structure| 1426050-43-2 Chemical Structure| 1426050-43-2

Structure of 1426050-43-2

Chemical Structure| 1426050-43-2

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Product Details of [ 1426050-43-2 ]

CAS No. :1426050-43-2
Formula : C8H6BrF2NO
M.W : 250.04
SMILES Code : O=C(N)CC1=C(F)C=C(Br)C=C1F

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Application In Synthesis of [ 1426050-43-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1426050-43-2 ]

[ 1426050-43-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 537033-52-6 ]
  • [ 1426050-43-2 ]
YieldReaction ConditionsOperation in experiment
78% With sulfuric acid; acetic acid; at 100℃; for 1h; To a solution of sulfuric acid (0.96 mL, 18.1 mmol) in acetic acid (20 mL) was slowly added <strong>[537033-52-6]2-(4-bromo-2,6-difluorophenyl)acetonitrile</strong> (0.84 g, 3.6 mmol) portion- wise while stirring, and the reaction mixture was then stirred for 1 h at 100 C. After cooling to 5 C, the mixture was carefully adjusted to pH 9 with 28-30%) aq ammonium hydroxide and then was extracted with chloroform (3 x 40 mL). The combined organic layers were dried over anhydrous sodium sulfate and concentrated in vacuo. Purification of the residue by flash chromatography (0-100%) ethyl acetate/hexanes) provided the title product (0.71 g, 78%). MS(ES+) m/e 250 [M+H]+; 1H NMR (400 MHz, CD2C12) δ ppm 3.60 (s, 2 H) 5.54 (br. s., 2 H) 7.10 - 7.21 (m, 2 H).
 

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