Structure of Dronedarone
CAS No.: 141626-36-0
Dronedarone is a therapeutic agent with a structural resemblance to amiodarone and a better side effect profile and it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF.
Synonyms: SR 33589
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Pandey, Akanksha M ; Malwal, Satish R ; Valladares-Delgado, Mariana ; Labrador-Fagundez, Liesangerli ; Stella, Bruno G ; Diaz-Perez, Luis Jose , et al.
Abstract: We investigated the effects of the tuberculosis drug candidate SQ109 (8a) and of its analog MeSQ109 (8b) against Leishmania mexicana in promastigote and amastigote forms, as well as against host cell macrophages finding potent activity (1.7 nM) for MeSQ109 against the intracellular forms, as well as low toxicity (~61 µM) to host cells, resulting in a selectivity index of ~36,000. We then investigated the mechanism of action of MeSQ109 finding that it targeted parasite mitochondria, collapsing the proton motive force, as well as targeting acidocalcisomes, rapidly increasing the intracellular Ca2+ concentration. Using an E. coli inverted membrane vesicle assay, we investigated the pH gradient collapse for SQ109 and 17 analogs finding that there was a significant correlation (on average R=0.67, p~0.008) between pH gradient collapse and cell growth inhibition in Trypanosoma brucei, T. cruzi, L. donovani and Plasmodium falciparum. We also investigated pH gradient collapse with other anti-leishmanial agents: azoles, antimonials, benzofurans, amphotericin B and miltefosine. The enhanced activity against intracellular trypanosomatids is seen with Leishmania spp. grown in macrophages but not with Trypanosoma cruzi in epithelial cells and is proposed to be due in part to host-based killing, based on the recent observation that SQ109 is known to convert macrophages to a pro-inflammatory (M1) phenotype.
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Keywords: Leishmaniasis ; Chagas disease ; Malaria ; SQ109 ; Acidocalcisomes ; PMF
Purchased from AmBeed: 1951-25-3 ; 141626-36-0
CAS No. : | 141626-36-0 |
Formula : | C31H44N2O5S |
M.W : | 556.76 |
SMILES Code : | CCCCC1=C(C2=C(O1)C=CC(NS(=O)(C)=O)=C2)C(C3=CC=C(C=C3)OCCCN(CCCC)CCCC)=O |
Synonyms : |
SR 33589
|
MDL No. : | MFCD00910331 |
InChI Key : | ZQTNQVWKHCQYLQ-UHFFFAOYSA-N |
Pubchem ID : | 208898 |
GHS Pictogram: | ![]() ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H373 |
Precautionary Statements: | P260-P264-P270-P301+P312+P330-P314-P501 |
In Vitro:
Concentration | Treated Time | Description | References |
PANC-1 cells | 15 μM or above | 12 hours | DH induced cell death in a dosage- and time-dependent manner, with only pyroptosis inhibitors and GSDMD silencing rescuing the cell death, indicating that DH triggered GSDMD-dependent pyroptosis | PMC11447222 |
HGC27 cells | 0, 3.125, 6.25, 12.5, 25, 50 μM | 24 and 48 hours | To verify DH's anti-tumor effect on GC cells, IC50 values were determined. The IC50 values for HGC27 and AGS cells at 24 hours were 9.504 and 8.739 μM, respectively, and at 48 hours were 6.587 and 4.188 μM. | PMC11491965 |
Rabbit sinoatrial node cells | 0.001 – 1 mM | 3 minutes | To investigate the effect of dronedarone on the Acetylcholine-activated K+ current (IK(ACh)). Results showed that dronedarone effectively blocks IK(ACh) with an IC50 value of 63 nM, and the block is voltage-independent. | PMC1572204 |
Xenopus laevis oocytes expressing KvLQT1/minK channels | 100 μM | 30 minutes | To investigate the effects of dronedarone on KvLQT1/minK currents, results showed that 100 μM dronedarone reduced KvLQT1/minK outward currents by 27.3% and tail currents by 50.3% | PMC1574095 |
Xenopus laevis oocytes expressing HERG channels | 9.2 μM (IC50) | 30 minutes | To investigate the acute electrophysiological effects of dronedarone on HERG channels, results showed that dronedarone blocked HERG channels with an IC50 of 9.2 μM and a maximum tail current reduction of 85.2% | PMC1574095 |
H9C2 cells | 1, 5, 10 μM | 6 hours | Dronedarone reversed Ang II-induced hypertrophy in H9C2 cells by upregulating the SIRT1/FOXO3/PKIA axis to suppress cell hypertrophy. | PMC11040268 |
AGS cells | 0, 0.5, 1, 2, 4 μM | 96 hours | To explore the effects of DH on gastric cancer cell proliferation. At 4 μM concentration, the inhibition rates of HGC27 and AGS cells were 60.2% and 88.4%, respectively. | PMC11491965 |
L. mexicana amastigotes inside infected macrophages (J774 cells) | 0.65 nM | 96 hours | Evaluate the inhibitory effect of Dronedarone on L. mexicana amastigotes inside infected macrophages, IC50 was 0.65 nM | PMC4023776 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Beagle dogs | Persistent atrial fibrillation model | Intravenous injection | 3 mg/kg | Single dose, observed for 21 hours | To evaluate anti-atrial fibrillatory effects and proarrhythmic risk, results showed that poyendarone and dronedarone had similar anti-atrial fibrillatory effects, but poyendarone significantly reduced the proarrhythmic risk. | PMC9532722 |
Pigs | Rapid atrial pacing (RAP) model | Intravenous injection | 10 mg·kg-1 | Single dose, lasting 6 hours | To evaluate the effect of Dronedarone on RAP-induced ventricular microcirculatory abnormalities. Results showed that Dronedarone abolished RAP-induced ventricular microcirculatory abnormalities by decreasing oxidative stress/ischaemia-related gene and protein expression in the ventricle. | PMC3417422 |
Sprague-Dawley rats | Transverse aortic constriction (TAC) surgery-induced myocardial hypertrophy model | Intragastric gavage | 90 mg/kg | Once daily for 8 weeks | Dronedarone alleviated TAC surgery-induced myocardial hypertrophy and impairment of cardiac function in rats by regulating the SIRT1/FOXO3/PKIA axis. | PMC11040268 |
Spontaneously hypertensive rats (SHR) | Hypertensive cardiac hypertrophy model | Oral | 100 mg/kg | Once daily for 14 days | To investigate the early regression effect of Dronedarone on hypertension-induced cardiac hypertrophy. Results showed that Dronedarone significantly reduced left ventricular mass, cardiomyocyte size, and collagen content, and improved myocardial metabolism. | PMC5697839 |
SCID mice | A549 lung adenocarcinoma xenograft model | Intraperitoneal injection | 20 mg/kg | Once daily for 12 days | Assessed the inhibitory effect of cimetidine on tumor growth, showing dose-dependent inhibition with the highest dose approaching the efficacy of the positive control doxorubicin | PMC6224430 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT01288352 | Atrial Fibrillation ... More >> Stroke Less << | Phase 4 | Active, not recruiting | November 2019 | Belgium ... More >> 14 Sites Different, Belgium Czech Republic 4 Sites Different, Czech Republic Denmark 2 Sites Different, Denmark France 2 Sites Different, France Germany 51 Sites Different, Germany Italy 12 Sites Different, Italy Netherlands 13 Sites Different, Netherlands Poland 5 Sites Different, Poland Spain 10 Sites Different, Spain Switzerland 5 Sites Different, Switzerland United Kingdom 22 Sites Different, United Kingdom Less << |
NCT03607123 | - | Active, not recruiting | July 4, 2022 | China, Jiangsu ... More >> The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, China, 201129 Less << | |
NCT00911508 | Atrial Fibrillation ... More >> Arrhythmia Less << | Not Applicable | Completed | - | - |
NCT02618577 | Atrial High Rate Episodes | Phase 3 | Recruiting | March 31, 2022 | Austria ... More >> Several Sites Recruiting Multiple Locations, Austria Belgium Several Sites Not yet recruiting Multiple Locations, Belgium Bulgaria Several Recruiting Multiple Locations, Bulgaria Czechia Several Recruiting Multiple Locations, Czechia France Several Recruiting Multiple Locations, France Germany Several Sites Recruiting Multiple Locations, Germany Hungary Several Recruiting Multiple Locations, Hungary Italy Several Recruiting Multiple Locations, Italy Netherlands Several Recruiting Multiple Locations, Netherlands Poland Several Recruiting Multiple Locations, Poland Portugal Several Recruiting Multiple Locations, Portugal Spain Several Recruiting Multiple Locations, Spain Sweden Several Recruiting Multiple Locations, Sweden Ukraine Several Recruiting Multiple Locations, Ukraine United Kingdom Several Recruiting Multiple Locations, United Kingdom Less << |
NCT03489395 | Atrial Fibrillation | Phase 2 | Recruiting | June 30, 2019 | Italy ... More >> Ospedale Madonna del Soccorso Active, not recruiting San Benedetto Del Tronto, Ascoli Piceno, Italy, 63074 Presidio Ospedaliero S. Maria delle Grazie Active, not recruiting Pozzuoli, Napoli, Italy, 80078 AORN S.ANNA e S.SEBASTIANO Not yet recruiting Caserta, Italy, 81100 Contact: Paolo Calabrò 00393284346963 paolo.calabro@unicampania.it Università degli Studi G. D'Annunzio Active, not recruiting Chieti, Italy, 66013 Ospedale P. Monaldi Not yet recruiting Napoli, Italy, 80131 Contact: Antonio D'Onofrio 0039337768956 donofrioant1@gmail.com Policlinico AO di Padova Not yet recruiting Padova, Italy, 35128 Contact: Vittorio Pengo 00393298324844 vittorio.pengo@unipd.it Policlinico Universitario Campus Bio-Medico Recruiting Roma, Italy, 00128 Contact: Giuseppe Patti 00393394296745 g.patti@unicampus.it Less << |
NCT02825979 | Atrial Fibrillation | Not Applicable | Recruiting | June 2022 | Canada, Alberta ... More >> Libin CV Calgary Recruiting Calgary, Alberta, Canada Contact: Jacques Rizkallah, MD Royal Alexandra Recruiting Edmonton, Alberta, Canada Contact: Evan Lockwood, MD Canada, British Columbia St. Paul's Hospital Recruiting Vancouver, British Columbia, Canada Contact: Dr. Zachary Laksman, MD Vancouver General Hospital Recruiting Vancouver, British Columbia, Canada Contact: Jason Andrade, MD Principal Investigator: Jason Andrade, MD Victoria Cardiac Arrhythmia Trials Recruiting Victoria, British Columbia, Canada, V8T 1Z4 Contact: Paul Novak, M.D. Canada, Nova Scotia Queen Elizabeth II Recruiting Halifax, Nova Scotia, Canada Contact: Dr. John Sapp, MD Canada, Ontario Hamilton Health Sciences Recruiting Hamilton, Ontario, Canada, L8L 2X2 Contact: Guy Amit, M.D. St. Mary's Kitchener Recruiting Kitchener, Ontario, Canada, N2M 1B2 Contact: Umjeet Jolly, M.D. London Health Sciences Centre Recruiting London, Ontario, Canada Contact: Peter Leong-Sit, MD Southlake Regional Health Centre Recruiting Newmarket, Ontario, Canada Contact: Dr. Atul Verma, MD University of Ottawa Heart Institute Not yet recruiting Ottawa, Ontario, Canada, K1Y4W7 Principal Investigator: Girish Nair, MD Rouge Valley Health System Recruiting Scarborough, Ontario, Canada Contact: Derek Yung, MD St. Michael's Hospital Recruiting Toronto, Ontario, Canada Contact: Paul Angaran, MD Canada, Quebec McGill University Health Centre Recruiting Montreal, Quebec, Canada Contact: Vidal Essebag, MD Hôpital du Sacré-Cœur de Montréal Recruiting Montréal, Quebec, Canada, H4J 1C5 Contact: Marcio Sturmer, M.D. Institut Universitaire de Cardiologie et de Pneumologie de Quebec Recruiting Quebec city, Quebec, Canada Contact: Jean Champagne, MD Le Centre hospitalier universitaire de Sherbrooke CHUS Recruiting Sherbrooke, Quebec, Canada Contact: Jean-Francois Roux, MD Canada, Saskatchewan University of Saskatchewan Recruiting Saskatoon, Saskatchewan, Canada Contact: Dr. Stephan Wardell, MD Less << |
NCT01411371 | Atrial Fibrillation ... More >> Heart Failure Less << | Not Applicable | Unknown | October 2011 | United Kingdom ... More >> Barts & The London NHS Trust Recruiting London, UK, United Kingdom, EC1A 7BE Contact: Ross J Hunter, MRCP 442076018639 ross.hunter@bartsandthelondon.nhs.uk Principal Investigator: Richard J Schilling, MD FRCP Sub-Investigator: Ross J Hunter, MRCP Less << |
NCT02294955 | Atrial Fibrillation ... More >> Quality of Life Less << | Not Applicable | Active, not recruiting | September 2018 | Sweden ... More >> Carina Blomström Lundqvist Uppsala, Sweden, S-75185 Less << |
NCT01306162 | Healthy | Phase 1 | Completed | - | Germany ... More >> 1160.112.1 Boehringer Ingelheim Investigational Site Ulm, Germany Less << |
NCT01856075 | - | Completed | - | Germany ... More >> Praxis fuer Kardiologie, Im Muehlenbach 2B Bonn, Germany, 53127 Less << | |
NCT01182376 | Atrial Fibrillation | Phase 3 | Completed | - | - |
NCT00697086 | Atrial Fibrillation | Phase 3 | Completed | - | Belgium ... More >> Sanofi-aventis Administrative Office Diegem, Belgium Czech Republic Sanofi-aventis Administrative Office Praha, Czech Republic France Sanofi-aventis Administrative Office Paris, France Italy Sanofi-aventis Administrative Office Milano, Italy Netherlands Sanofi-aventis Administrative Office Gouda, Netherlands Poland Sanofi-aventis Administrative Office Warszawa, Poland Spain Sanofi-aventis Administrative Office Barcelona, Spain Sweden Sanofi-aventis Administrative Office Bromma, Sweden Switzerland Sanofi-aventis Administrative Office Geneva, Switzerland Less << |
NCT01182376 | - | Completed | - | - | |
NCT01140581 | Atrial Fibrillation | Phase 4 | Completed | - | - |
NCT01213368 | Atrial Fibrillation | Phase 2 | Completed | - | Japan ... More >> Investigational Site Number 392022 Hiroshima-Shi, Japan Investigational Site Number 392018 Kagoshima-Shi, Japan Investigational Site Number 392005 Kasama-Shi, Japan Investigational Site Number 392014 Kawanishi-Shi, Japan Investigational Site Number 392008 Kawasaki-Shi, Japan Investigational Site Number 392007 Kisarazu-Shi, Japan Investigational Site Number 392012 Kobe-Shi, Japan Investigational Site Number 392013 Kobe-Shi, Japan Investigational Site Number 392003 Koriyama-Shi, Japan Investigational Site Number 392017 Kurume-Shi, Japan Investigational Site Number 392023 Miyazaki-Shi, Japan Investigational Site Number 392009 Nagano-Shi, Japan Investigational Site Number 392019 Nagasaki-Shi, Japan Investigational Site Number 392010 Osaka-Shi, Japan Investigational Site Number 392021 Sapporo-Shi, Japan Investigational Site Number 392025 Sapporo-Shi, Japan Investigational Site Number 392002 Sendai-Shi, Japan Investigational Site Number 392004 Shirakawa-Shi, Japan Investigational Site Number 392016 Shunan-Shi, Japan Investigational Site Number 392020 Suwa-Shi, Japan Investigational Site Number 392006 Takasaki-Shi, Japan Investigational Site Number 392001 Tomakomai-Shi, Japan Investigational Site Number 392024 Toshima-Ku, Japan Investigational Site Number 392015 Ube-Shi, Japan Investigational Site Number 392011 Yao-Shi, Japan Less << |
NCT01522651 | Atrial Fibrillation | Phase 2 | Completed | - | - |
NCT00174785 | - | Completed | - | - | |
NCT01306162 | - | Completed | - | - | |
NCT00259376 | Atrial Fibrillation ... More >> Atrial Flutter Less << | Phase 3 | Completed | - | United States, New Jersey ... More >> Sanofi-Aventis Administrative Office Bridgewater, New Jersey, United States, 08807 Argentina Sanofi-Aventis Administrative Office Buenos Aires, Argentina Australia sanofi-aventis Australia administrative office Macquarie Park, Australia Canada Sanofi-Aventis Administrative Office Laval, Canada South Africa Sanofi-Aventis Administrative Office Midrand, South Africa Less << |
NCT01047566 | Atrial Fibrillation | Phase 4 | Completed | - | Netherlands ... More >> Sanofi-Aventis Administrative Office PE Gouda, Netherlands Less << |
NCT00174785 | Atrial Fibrillation ... More >> Atrial Flutter Less << | Phase 3 | Completed | - | - |
NCT01430806 | ICD ICD SHOCK... More >>S DRONEDARONE Less << | Not Applicable | Unknown | December 2015 | - |
NCT00259428 | Atrial Fibrillation ... More >> Atrial Flutter Less << | Phase 3 | Completed | - | Belgium ... More >> Sanofi-Aventis Administrative Office Diegem, Belgium Czech Republic Sanofi-Aventis Administrative Office Praha, Czech Republic Denmark Sanofi-Aventis Administrative Office Horsholm, Denmark Finland Sanofi-Aventis Administrative Office Helsinki, Finland France Sanofi-Aventis Administrative Office Paris, France Germany Sanofi-Aventis Administrative Office Berlin, Germany Hungary Sanofi- Aventis Administrative Office Budapest, Hungary Italy Sanofi-Aventis Administrative Office Milano, Italy Netherlands Sanofi-Aventis Administrative Office Gouda, Netherlands Poland Sanofi-Aventis Administrative Office Warszawa, Poland Spain Sanofi-Aventis Administrative Office Barcelona, Spain United Kingdom Sanofi-Aventis Administrative Office Guildford, United Kingdom Less << |
NCT00696631 | Congestive Heart Failure | Phase 3 | Terminated(Terminated as the a... More >>ctive treatment was associated with an increased hazard) Less << | - | Denmark ... More >> Sanofi-aventis Administrative Office Horsholm, Denmark Hungary Sanofi-aventis Administrative Office Budapest, Hungary Netherlands Sanofi-aventis Administrative Office Gouda, Netherlands Norway Sanofi-aventis Administrative Office Lysaker, Norway Poland Sanofi-aventis Administrative Office Warszawa, Poland Sweden Sanofi-aventis Administrative Office Bromma, Sweden Less << |
NCT01266681 | Atrial Fibrillation | Not Applicable | Unknown | - | United Kingdom ... More >> Eastbourne General Hospital Not yet recruiting Eastbourne, East Sussex, United Kingdom, BN21 2UD Sub-Investigator: Oliver Waller, Bsc (hons) Less << |
NCT01991119 | Atrial Fibrillation | Not Applicable | Completed | - | Korea, Republic of ... More >> Cardiac and Vascular Center Seoul, Korea, Republic of, 135-710 Less << |
NCT00489736 | - | Completed | - | - | |
NCT00489736 | Atrial Fibrillation | Phase 3 | Completed | - | - |
NCT01026090 | Atrial Fibrillation | Phase 4 | Terminated('Sponsor decision f... More >>ollowing recruitment issues, not related to any safety concerns in the study) Less << | - | Canada ... More >> Investigational Site Number 1240033 Abbotsford, Canada, V2S3N5 Investigational Site Number 1240026 Barrie, Canada, L4M4S5 Investigational Site Number 1240050 Calgary, Canada, T2E7C5 Investigational Site Number 1240010 Cambridge, Canada, N1R6V6 Investigational Site Number 1240049 Edmonton, Canada, T5H4B9 Investigational Site Number 1240005 Granby, Canada, J2G1T7 Investigational Site Number 1240001 Greenfield Park, Canada, J4V2G8 Investigational Site Number 1240046 Grimsby, Canada, L3M 1P3 Investigational Site Number 1240040 Hamilton, Canada, L8L 2X2 Investigational Site Number 1240037 Hamilton, Canada, L8N 3Z5 Investigational Site Number 1240044 Kingston, Canada, K7L2V7 Investigational Site Number 1240029 Kitchener, Canada, N2N2A8 Investigational Site Number 1240013 Laval, Canada, H7S2M5 Investigational Site Number 1240043 Levis, Canada, G6V3Z1 Investigational Site Number 1240038 Maple Ridge, Canada, V2X5Z6 Investigational Site Number 1240023 Montreal, Canada, H1T1C8 Investigational Site Number 1240006 Montreal, Canada, H3G 1A4 Investigational Site Number 1240008 Montreal, Canada, H4J1C5 Investigational Site Number 1240018 Newmarket, Canada, L3Y8C3 Investigational Site Number 1240012 Niagara Falls, Canada, L2E7H1 Investigational Site Number 1240020 North York, Canada, M2J1W8 Investigational Site Number 1240015 Oshawa, Canada, L1J2J9 Investigational Site Number 1240036 Oshawa, Canada Investigational Site Number 1240024 Ottawa, Canada, K1Y4W7 Investigational Site Number 1240032 Ottawa, Canada, K2G3M8 Investigational Site Number 1240056 Red Deer, Canada, T4N4E7 Investigational Site Number 1240053 Saskatoon, Canada, S7N0W8 Investigational Site Number 1240016 Scarborough, Canada, M1E5E9 Investigational Site Number 1240027 Sherbrooke, Canada, J1H 5N4 Investigational Site Number 1240003 St-Charles Borromee, Canada, J6E6J2 Investigational Site Number 1240007 St-Georges, Canada, G5Y 4T8 Investigational Site Number 1240041 St. John, Canada, E2L 4L2 Investigational Site Number 1240002 Ste-Foy, Canada, G1V4G5 Investigational Site Number 1240021 Sudbury, Canada, P3C5K7 Investigational Site Number 1240039 Sudbury, Canada, P3E2N8 Investigational Site Number 1240025 Toronto, Canada, M4N3M5 Investigational Site Number 1240011 Toronto, Canada, M5C 2T2 Investigational Site Number 1240019 Toronto, Canada, M5G2C4 Investigational Site Number 1240009 Trois-Rivières, Canada, G8Z 4K4 Investigational Site Number 1240047 Vancouver, Canada, V5Z1M6 Investigational Site Number 1240035 Victoria, Canada, V8R4R2 Investigational Site Number 1240014 Willowdale, Canada, M2K2W2 Investigational Site Number 1240051 Windsor, Canada, N8X3N9 Less << |
NCT01151137 | Atrial Fibrillation | Phase 3 | Terminated(The study was stopp... More >>ed because of safety concerns) Less << | - | - |
NCT01151137 | - | Terminated(The study was stopp... More >>ed because of safety concerns) Less << | - | - | |
NCT01198873 | Atrial Fibrillation | Phase 4 | Terminated | - | - |
NCT01135017 | Atrial Fibrillation | Phase 4 | Terminated | - | - |
NCT01135017 | - | Terminated | - | - | |
NCT01198873 | - | Terminated | - | - | |
NCT01070667 | Paroxysmal Atrial Fibrillation | Phase 4 | Unknown | March 2010 | United Kingdom ... More >> Eastbourne DGH Not yet recruiting Eastbourne, East Sussex, United Kingdom, BN21 2UD Contact: Steven J Podd, MA, MBBS 01323417400 ext 4132 steven.podd@esht.nhs.uk Contact: A N Sulke, MD 01323417400 ext 5869 pamela.morley@esht.nhs.uk Less << |
NCT01199081 | Atrial Fibrillation | PHASE4 | COMPLETED | 2025-04-12 | Investigational Site Number 17... More >>0001, Bogota, Colombia|Investigational Site Number 170002, Bucaramanga, Colombia|Investigational Site Number 170003, Cartagena, Colombia|Investigational Site Number 170006, Cartagena, Colombia|Investigational Site Number 170007, Floridablanca, Colombia|Investigational Site Number 170005, Medellin, Colombia|Investigational Site Number 203005, Brno, Czech Republic|Investigational Site Number 203003, Kladno, 27280, Czech Republic|Investigational Site Number 203002, Olomouc, Czech Republic|Investigational Site Number 203007, Prachatice, 38301, Czech Republic|Investigational Site Number 203001, Praha 2, 12808, Czech Republic|Investigational Site Number 203004, Praha 9, 19000, Czech Republic|Investigational Site Number 203008, Pribram, 26101, Czech Republic|Investigational Site Number 203006, Sternberk, 78501, Czech Republic|Investigational Site Number 208-001, Aarhus, 8000, Denmark|Investigational Site Number 208-002, Copenhagen, 2400, Denmark|Investigational Site Number 208-003, K?benhavn S., 2300, Denmark|Investigational Site Number 250-004, AMIENS Cedex 1, 80054, France|Investigational Site Number 250-005, Boulogne Billancourt Cedex, 92104, France|Investigational Site Number 250-003, Chambray Les Tours Cedex, 37171, France|Investigational Site Number 250-002, GRENOBLE cedex, 38043, France|Investigational Site Number 250-001, Montpellier, 34295, France|Investigational Site Number 250-006, TOULOUSE Cedex 9, 31059, France|Investigational Site Number 276-001, Bonn, 53105, Germany|Investigational Site Number 276-002, Chemnitz, 09111, Germany|Investigational Site Number 276-005, Hagen, 58095, Germany|Investigational Site Number 276-003, Nürnberg, 90402, Germany|Investigational Site Number 276-004, Wermsdorf, 04779, Germany|Investigational Site Number 484003, Aguascalientes, 20020, Mexico|Investigational Site Number 484002, Mexico, 11340, Mexico|Investigational Site Number 484001, San Luis Potosi, 72244, Mexico|Investigational Site Number 484005, San Luis Potosi, 78200, Mexico|Investigational Site Number 484004, Torreon, 27000, Mexico|Investigational Site Number 484006, Zapopan, 45200, Mexico|Investigational Site Number 724004, Barakaldo, 48903, Spain|Investigational Site Number 724001, Barcelona, 08036, Spain|Investigational Site Number 724005, Hospitalet de Llobregat, 08907, Spain|Investigational Site Number 724002, Madrid, 28046, Spain|Investigational Site Number 724003, Málaga, 29010, Spain|Investigational Site Number 724006, Valdemoro, 28342, Spain Less << |
NCT05130268 | Atrial Fibrillation | PHASE4 | COMPLETED | 2024-06-30 | Thomas Hospital, Fairhope, Ala... More >>bama, 36532, United States|Mercy Gilbert Medical Center, Gilbert, Arizona, 85297, United States|HonorHealth Scottsdale Shea Medical Center, Scottsdale, Arizona, 85260, United States|Los Angeles Medical Center (Kaiser Permenente), Los Angeles, California, 90027, United States|West Los Angeles Medical Center, Los Angeles, California, 90034, United States|Cedars Sinai Medical Center, Los Angeles, California, 90048, United States|UC Irvine Medical Center (AKA UCI Health), Orange, California, 92868, United States|Los Robles Health System - Los Robles Regional Medical Center, Thousand Oaks, California, 91360, United States|UCLA Medical Center - Harbor, Torrance, California, 90502, United States|Colorado Heart & Vascular Group - St. Anthony's Hospital, Lakewood, Colorado, 80228, United States|Colorado Heart & Vascular Group - St. Anthony's North Health Campus, Westminster, Colorado, 80023, United States|Christiana Hospital, Newark, Delaware, 19718, United States|First Coast Cardiovascular Institute, Jacksonville, Florida, 32256, United States|Ocean Wellness Center, LLC, Miami Gardens, Florida, 33169, United States|Pharma Medical Innovations, Miami Lakes, Florida, 33014, United States|The Angel Medical Research, Miami Lakes, Florida, 33156, United States|Enmanuel Advanced Research Center, LLC, Miami, Florida, 33126, United States|Life Spring Research Foundation, LLC, Miami, Florida, 33130, United States|Nouvelle Clinical Research LLC, Miami, Florida, 33130, United States|Golden Touch Clinical Research, Miami, Florida, 33144, United States|Excellence Medical And Research, LLC, Miami, Florida, 33169, United States|The Miami Research Group, Miami, Florida, 33186, United States|Northside Hospital, Saint Petersburg, Florida, 33709, United States|Guardian Angel Research Center, Tampa, Florida, 33614, United States|Northeast Georgia Medical Center, Gainesville, Georgia, 30501, United States|Georgia Arrhythmia Consultants and Research Institute, Macon, Georgia, 31201, United States|Wellstar Kennestone Hospital, Marietta, Georgia, 30062, United States|Mt Sinai Hospital Medical Center, Chicago, Illinois, 60608, United States|Rush University Medical Center, Chicago, Illinois, 60612, United States|University of Illinois Hospital, Chicago, Illinois, 60612, United States|Riverside Medical Center, Kankakee, Illinois, 60901, United States|Loyola University Medical Center, Maywood, Illinois, 60153, United States|Captain James A Lovell Federal Health Care Center, North Chicago, Illinois, 60064, United States|Proctor Community Hospital, Peoria, Illinois, 61614, United States|Methodist Medical Center of Illinois, Peoria, Illinois, 61636, United States|Trinity Rock Island, Rock Island, Illinois, 61201, United States|St. Elizabeth's Hospital of the Hospital Sisters of the Third Order of St. Francis, Springfield, Illinois, 62769, United States|St. John's Hospital of the Hospital Sisters of the Third Order of St. Francis, Springfield, Illinois, 62769, United States|Carle Foundation Hospital, Urbana, Illinois, 61801, United States|Parkview Hospital, Inc., Fort Wayne, Indiana, 46845, United States|Ascension St Vincent Hospital - Indianapolis, Indianapolis, Indiana, 46260, United States|Kansas City Heart and Vascular Specialists at Providence Medical Center, Kansas City, Kansas, 66112, United States|Overland Park Regional Medical Center, Overland Park, Kansas, 66215, United States|Baptist Health Lexington, Lexington, Kentucky, 40223, United States|Saint Joseph Hospital, Lexington, Kentucky, 40504, United States|Heart Clinic of Hammond, Hammond, Louisiana, 70403, United States|Tulane Medical Center, New Orleans, Louisiana, 70112, United States|Luminis Health Anne Arundel Medical Center, Annapolis, Maryland, 21401, United States|Saint Agnes Hospital, Baltimore, Maryland, 21229, United States|Adventist Healthcare Shady Grove Medical Center, Rockville, Maryland, 20850, United States|Brigham and Womens Hospital, Boston, Massachusetts, 02115, United States|McLaren Bay Region, Bay City, Michigan, 48708, United States|DMC Harper University Hospital (AKA Wayne State University Hospital), Detroit, Michigan, 48201, United States|Sparrow Hospital, Lansing, Michigan, 48912, United States|McLaren Macomb, Mount Clemens, Michigan, 48043, United States|Trinity Health Ann Arbor Hospital - Michigan Heart, Ypsilanti, Michigan, 48197, United States|Minneapolis VA Health Care System, Minneapolis, Minnesota, 55417, United States|University Hospital - University of Missouri, Columbia, Missouri, 65211, United States|Barnes-Jewish Hospital (AKA Washington Univ), Saint Louis, Missouri, 63110, United States|SSM Health Saint Louis University Hospital, Saint Louis, Missouri, 63110, United States|Mercy Hospital Springfield, Springfield, Missouri, 65804, United States|CHI Health Creighton University Medical Center - Bergan Mercy, Omaha, Nebraska, 68124, United States|Cooper University Hospital, Camden, New Jersey, 08103, United States|The Valley Hospital, Ridgewood, New Jersey, 07450, United States|Albany Medical Center, Albany, New York, 12208, United States|NYC Health and Hospitals - Lincoln, Bronx, New York, 10451, United States|NYC Health and Hospitals - Jacobi, Bronx, New York, 10461, United States|NYC Health and Hospitals - North Central Bronx, Bronx, New York, 10467, United States|NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, 10032, United States|Memorial Sloan Kettering, New York, New York, 10065, United States|DiGiovanna Institute for Medical Education & Research, North Massapequa, New York, 11758, United States|Duke University Hospital, Durham, North Carolina, 27705, United States|Durham VA Health Care System, Durham, North Carolina, 27705, United States|WakeMed Raleigh Campus, Raleigh, North Carolina, 27610, United States|New Hanover Regional Medical Center, Wilmington, North Carolina, 28411, United States|Trinity Hospital, Minot, North Dakota, 58702, United States|The MetroHealth System, Cleveland, Ohio, 44109, United States|Kettering Health Dayton, Dayton, Ohio, 45405, United States|Miami Valley Hospital, Dayton, Ohio, 45409, United States|Kettering Medical Center, Kettering, Ohio, 45429, United States|McLaren - St Lukes Hospital, Maumee, Ohio, 43537, United States|Wooster Community Hospital Health System, Wooster, Ohio, 44691, United States|Oklahoma City VA Health Care System, Oklahoma City, Oklahoma, 73104, United States|University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, United States|Penn State Health Holy Spirit Medical Center, Camp Hill, Pennsylvania, 17011, United States|Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, 17033, United States|Penn State Health St Joseph Medical Center - Main Campus, Reading, Pennsylvania, 19605, United States|Ascension Saint Thomas Midtown, Nashville, Tennessee, 37236, United States|Ascension Seton Medical Center Austin, Austin, Texas, 78723, United States|Texas Health Fort Worth (FKA Texas Health Harris Methodist Hospital Fort Worth), Fort Worth, Texas, 76104, United States|Memorial Hermann - Texas Medical Center, Houston, Texas, 77030, United States|Texas Institute of Cardiology, McKinney, Texas, 75071, United States|Synapse Clinical Research, Missouri City, Texas, 77549, United States|University Hospital at University of Texas San Antonio, San Antonio, Texas, 78229, United States|University of Utah Hospital, Salt Lake City, Utah, 84132, United States|Chippenham and Johnston Willis Medical Center, Richmond, Virginia, 23225, United States|Hunter Holmes McGuire VA Medical Center (AKA Richmond VA Medical Center), Richmond, Virginia, 23249, United States|JW Ruby Memorial Hospital, Morgantown, West Virginia, 26506, United States|Mayo Clinic Hospital - Franciscan Healthcare La Crosse, La Crosse, Wisconsin, 54601, United States|UW Health at the American Center (AKA UW Health East Madison Hospital), Madison, Wisconsin, 53718, United States|University Hospital - University of Wisconsin-Madison, Madison, Wisconsin, 53792, United States|Marshfield Medical Center, Marshfield, Wisconsin, 54449, United States|Marshfield Medical Center, Weston, Wisconsin, 54476, United States Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() | 1mg | 5mg | 10mg |
1 mM 5 mM 10 mM | 1.80mL 0.36mL 0.18mL | 8.98mL 1.80mL 0.90mL | 17.96mL 3.59mL 1.80mL | |
Dissolving Methods | in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
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