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CAS No. :	141430-65-1
Formula :	C₁₈H₁₇N₃O₄S
M.W :	371.41
SMILES Code :	O=S(C1=CC=C(C=C1)OC)(NC2=CC=CN=C2NC3=CC=C(C=C3)O)=O
Synonyms :	E7010
MDL No. :	MFCD00910291
InChI Key :	URCVCIZFVQDVPM-UHFFFAOYSA-N
Pubchem ID :	3035714

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

SK-Mel-2	262.2 nM	5 days	Evaluate the anti-proliferative effect of ABT-751 in melanoma cell lines, IC50 value was 262.2 nM.	PMC11043045
WM-266-4	298.9 nM	5 days	Evaluate the anti-proliferative effect of ABT-751 in melanoma cell lines, IC50 value was 298.9 nM.	PMC11043045
WM-115	208.2 nM	5 days	Evaluate the anti-proliferative effect of ABT-751 in melanoma cell lines, IC50 value was 208.2 nM.	PMC11043045
Sk-Mel-28	697.9 nM	5 days	Evaluate the anti-proliferative effect of ABT-751 in melanoma cell lines, IC50 value was 697.9 nM.	PMC11043045
Sk-Mel-5	259.7 nM	5 days	Evaluate the anti-proliferative effect of ABT-751 in melanoma cell lines, IC50 value was 259.7 nM.	PMC11043045
Malme-3M	465.2 nM	5 days	Evaluate the anti-proliferative effect of ABT-751 in melanoma cell lines, IC50 value was 465.2 nM.	PMC11043045
Lox-IMVI	1007.2 nM	5 days	Evaluate the anti-proliferative effect of ABT-751 in melanoma cell lines, IC50 value was 1007.2 nM.	PMC11043045
J82	0.7 μM	24 hours	ABT-751 induced G2/M cell cycle arrest, decreased cell number in the S phase of the cell cycle and suppressed colony formation/independent cell growth, accompanied with alterations of the protein levels of several cell cycle regulators.	PMC7835924
BFTC905	0.6 μM	24 hours	ABT-751 induced G2/M cell cycle arrest, decreased cell number in the S phase of the cell cycle and suppressed colony formation/independent cell growth, accompanied with alterations of the protein levels of several cell cycle regulators.	PMC7835924
GBM CD105+ cells	0.5 μM and 10 μM	48 hours and 96 hours	Screening for effective drugs against GBM CD105+ cells, ABT-751 showed robust toxic effects on GBM CD105+ cells.	PMC9426031
Lung cancer A549 cell	4.58 μM	72 hours	Evaluate the growth inhibitory activity of ABT-751 against A549 cells, with a GI50 value of 4.58 μM.	PMC6359563
Breast cancer MCF-7 cell	0.88 μM	72 hours	Evaluate the growth inhibitory activity of ABT-751 against MCF-7 cells, with a GI50 value of 0.88 μM.	PMC6359563
Leukemia K562 cell	0.74 μM	72 hours	Evaluate the growth inhibitory activity of ABT-751 against K562 cells, with a GI50 value of 0.74 μM.	PMC6359563
MCF-7 CC cells	10μM	24 hours	To evaluate the effects of ABT-751 on microtubule formation, results showed that MCF-7 CC cells were less sensitive to ABT-751, with microtubule fibers not completely disappearing at 10μM.	PMC5546696
MCF-7 TXT cells	10μM	24 hours	To evaluate the effects of ABT-751 on microtubule formation, results showed that MCF-7 TXT cells were more sensitive to ABT-751, with microtubule fibers completely disappearing at 10μM.	PMC5546696

NCT00047489	Hematological Malignancies	PHASE1	COMPLETED	2025-01-05	The University of Texas M.D. A... More >>nderson Cancer Center, Houston, Texas, 77030, United States Less <<
NCT00063102	Breast Cancer	PHASE2	COMPLETED	2025-08-04	Oncology-Hematology Group of S... More >>outh Florida, Miami, Florida, 33176, United States\|Clinical Research Network, Inc., Plantation, Florida, 33324, United States\|Georgia Cancer Specialists, Atlanta, Georgia, United States\|Northwestern University Medical School Division of Hematology/Oncology, Chicago, Illinois, 60611, United States\|Indiana University Cancer Center Section of of Hemtology/Oncology Indiana Cancer Pavilion, Indianapolis, Indiana, 46202, United States\|Northern Indiana Cancer Research Consortium, South Bend, Indiana, United States\|Oncology & Hemotology Associates of Kansas City, PA, Kansas City, Missouri, 64111, United States\|Texas Oncology, Dallas, Texas, United States Less <<
NCT00073151	Non-Small Cell Lung Cancer	PHASE2	COMPLETED	2025-01-06	Oncology Hematology Group of S... More >>outh Florida, Miami, Florida, United States\|Florida Cancer Institute, New Port Richey, Florida, United States\|University of Chicago Medical Center, Chicago, Illinois, 60637-1460, United States\|University of Maryland Greenbaum Cancer Center, Baltimore, Maryland, 21201-1595, United States\|Oncology & Hematology Associates of Kansas City, PA, Kansas City, Missouri, 64111, United States\|Washington University School of Medicine, St. Louis, Missouri, 63110-1093, United States\|Albany Regional Cancer Center, Albany, New York, United States\|Raleigh Hematology Oncology, Cary, North Carolina, United States\|Dayton Oncology and Hematology, Kettering, Ohio, United States\|Cancer Care Associates, Oklahoma City, Oklahoma, United States\|Cancer Centers of the Carolinas, Greenville, South Carolina, United States\|West Cancer Clinic, Memphis, Tennessee, 38120, United States\|Texas Oncology, Dallas, Texas, United States\|Texas Oncology, Ft. Worth, Texas, United States\|Cancer Care Northwest, Spokane, Washington, United States\|Northwest Cancer Specialists, Vancouver, Washington, United States\|University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin, 53792-5666, United States Less <<
NCT00471718	Prostate Cancer	PHASE1\|PHASE2	TERMINATED	2025-08-09	Vanderbilt-Ingram Cancer Cente... More >>r, Nashville, Tennessee, 37232-6838, United States Less <<
NCT00073138	Colorectal Cancer	PHASE2	COMPLETED	2025-02-05	University of Southern Califor... More >>nia, Los Angeles, California, 90089, United States\|Cancer Institute Medical Group, Santa Monica, California, 90095-3961, United States\|Northwestern University, Chicago, Illinois, 60611-5933, United States\|University of Chicago Medical Center, Chicago, Illinois, 60637, United States\|Duke University Medical Center, Durham, North Carolina, 27710, United States\|University of Wisconsin Medical Center, Madison, Wisconsin, 53792, United States Less <<
NCT00036959	Brain and Central Nervous Syst... More >>em Tumors\|Childhood Germ Cell Tumor\|Extragonadal Germ Cell Tumor\|Kidney Cancer\|Liver Cancer\|Neuroblastoma\|Ovarian Cancer\|Sarcoma\|Unspecified Childhood Solid Tumor, Protocol Specific Less <<	PHASE1	COMPLETED	2025-02-10	Children's Memorial Hospital -... More >> Chicago, Chicago, Illinois, 60614, United States\|Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office, Bethesda, Maryland, 20892-1182, United States\|Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104-4318, United States Less <<
NCT00073112	Renal Cell Cancer	PHASE2	COMPLETED	2025-09-06	Arizona Cancer Research Center... More >>, Tucson, Arizona, 85712, United States\|UCLA School of Medicine, Los Angeles, California, 90024, United States\|Clinical Trials + Research Associates, Montebello, California, 90640, United States\|US Oncology Inc Rocky Mountain Cancer Centers, Denver, Colorado, 80218, United States\|Oncology Hematology Group of South Florida, Miami, Florida, United States\|US Oncology Inc Florida Cancer Institute, New Port Richey, Florida, 34652, United States\|US Oncology Inc Ocala Oncology Center, Ocala, Florida, 34474, United States\|US Oncology Inc Cancer Centers of Florida, P.A., Orlando, Florida, 32806, United States\|University of Chicago Medical Center, Chicago, Illinois, 60637-1471, United States\|Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, 21231, United States\|US Oncology Inc Raleigh Hematology Oncology Clinic, Cary, North Carolina, 27511, United States\|US Oncology Inc Dayton Oncology & Hematology P.A., Kettering, Ohio, 45409, United States\|US Oncology Inc Cancer Care Accociates-Mercy Campus, Oklahoma City, Oklahoma, 73120, United States\|US Oncology Inc Cancer Centers of the Carolinas, Greenville, South Carolina, 29615, United States\|West Cancer Clinic, Memphis, Tennessee, 38120, United States\|Vanderbilt Ingram Cancer Center, Nashville, Tennessee, 37232-6307, United States\|US Oncology Inc Tyler Cancer Center, Tyler, Texas, 75702, United States\|US Oncology Inc Cancer Care Northwest-North, Spokane, Washington, 99218, United States\|US Oncology Inc Northwest Cancer Specialists, Vancouver, Washington, 98684, United States\|B.C. Vancouver Cancer Agency, Vancouver, British Columbia, V5Z 4E6CAN, Canada\|Queen Elizabeth II Health Science Centre, Halifax, Nova Scotia, B3H2Y9, Canada\|McMaster University, Hamilton, Ontario, L8N 4A6, Canada\|McGill University, Montreal, Quebec, Canada Less <<

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CAS No.: 141430-65-1

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CAS No.: 141430-65-1

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Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	2.69mL 0.54mL 0.27mL	13.46mL 2.69mL 1.35mL	26.92mL 5.38mL 2.69mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed