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Chemical Structure| 141306-08-3 Chemical Structure| 141306-08-3
Chemical Structure| 141306-08-3

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5-Chloro-3-(4-fluorophenyl)-1H-indole

CAS No.: 141306-08-3

,97%

4.5 *For Research Use Only !

Cat. No.: A792756 Purity: 97%

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    Product Details of [ 141306-08-3 ]

    CAS No. :141306-08-3
    Formula : C14H9ClFN
    M.W : 245.68
    SMILES Code : FC1=CC=C(C2=CNC3=C2C=C(Cl)C=C3)C=C1

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    Application In Synthesis of [ 141306-08-3 ]

    * All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

    • Downstream synthetic route of [ 141306-08-3 ]

    [ 141306-08-3 ] Synthesis Path-Downstream   1~1

    • 1
    • [ 1477-50-5 ]
    • [ 101125-32-0 ]
    • [ 141306-08-3 ]
    YieldReaction ConditionsOperation in experiment
    In quinoline; diethyl ether; A mixture of the crude indole-2-carboxylic acid (55.0 g), Cu (2.0 g) and quinoline (1.0 l) was refluxed for 2.5 h, cooled and filtered. The filtrate was poured into water (800 ml) and extracted with diethyl ether (2*800 ml). The combined organic phases were succesively washed with 1N hydrochloric acid (4*1.0 l), washed with brine (1.0 l) and dried (Na2 SO4). Evaporation of the solvent in vacuo gave the title compound which was precipitated from diethyl ether. Yield: 43.6 g, mp 98-100 C. In a corresponding manner the following indole derivatives were prepared: 5-Chloro-3-(4-fluorophenyl)-1H-indole 1b, mp 81-83 C.
     

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