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Chemical Structure| 1407232-79-4 Chemical Structure| 1407232-79-4

Structure of 1407232-79-4

Chemical Structure| 1407232-79-4

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Product Details of [ 1407232-79-4 ]

CAS No. :1407232-79-4
Formula : C14H15NO3
M.W : 245.27
SMILES Code : O=C(O)[C@@H](N(CC1=C2C=CC=C1)C2=O)CC3CC3
MDL No. :MFCD34183062

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Application In Synthesis of [ 1407232-79-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1407232-79-4 ]

[ 1407232-79-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 102735-53-5 ]
  • [ 643-79-8 ]
  • [ 1407232-79-4 ]
YieldReaction ConditionsOperation in experiment
30% In acetonitrile; for 18h;Reflux; Inert atmosphere; Example 10(S)-3-Cyclopropyl-N-[1-(2-methoxy-2-methyl-propyl)-1H-pyrazol-3-yl]-2-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamideA solution of benzene-1,2-dicarbaldehyde (340 mg, 2.55 mmol) and (S)-2-amino-3-cyclopropyl-propionic acid (300 mg, 2.32 mmol) in acetonitrile (15 mL) was heated to reflux for 18 h.The solution was cooled, concentrated and the residue redissolved in methylene chloride (50 mL).The solution was extracted with a saturated sodium bicarbonate solution.The layers were separated and the aqueous phase was acidified (pH=2) with hydrochloric acid (3N), extracted with methylene chloride (2*50 mL).The organic phases were combined, dried over magnesium sulfate, filtered and evaporated to give (S)-3-cyclopropyl-2-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionic (170 mg, 30percent) as a yellow solid: LR-ES(+) m/e calcd for C14H15NO3 [M+H]+ 246.29, observed 246.2; 1H NMR (DMSO-d6) delta7.24-7.94 (m, 4H), 4.83 (dd, J=10.6, 4.8 Hz, 1H), 4.54 (s, 2H), 3.16 (d, J=3.6 Hz, 1H), 1.90-2.16 (m, 1H), 1.54-1.79 (m, 1H), 0.65 (dd, J=7.8, 5.4 Hz, 1H), 0.29-0.48 (m, 2H), -0.01-0.19 (m, 2H).
 

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