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Chemical Structure| 1392512-54-7 Chemical Structure| 1392512-54-7

Structure of 1392512-54-7

Chemical Structure| 1392512-54-7

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Product Details of [ 1392512-54-7 ]

CAS No. :1392512-54-7
Formula : C8H10BFO2
M.W : 167.97
SMILES Code : OB(C1=C(C)C=C(F)C=C1C)O
MDL No. :MFCD23712929
InChI Key :GNTWJIXJCKRFJD-UHFFFAOYSA-N
Pubchem ID :66552110

Safety of [ 1392512-54-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P261-P280-P305+P351+P338-P304+P340

Application In Synthesis of [ 1392512-54-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1392512-54-7 ]

[ 1392512-54-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 121-43-7 ]
  • [ 14659-58-6 ]
  • [ 1392512-54-7 ]
  • 2
  • [ 5419-55-6 ]
  • [ 14659-58-6 ]
  • [ 7732-18-5 ]
  • [ 1392512-54-7 ]
YieldReaction ConditionsOperation in experiment
To a solution of <strong>[14659-58-6]2-bromo-5-fluoro-1,3-dimethylbenzene</strong> (2 g, 9.9 mmol) in THF (20 mL) under N2 atmosphere was added n-BuLi (2.5 M in hexane, 6 mL, 14.8 mmol) dropwise at -78 C. The reaction mixture was stirred at -78 C. for 30 min. Triisopropyl borate (5.58 g, 29.7 mmol) was added. The mixture was warmed to room temperature and stirred for 1 hour. HCl (5 M, 20 mL) was added and the mixture was stirred at room temperature for 10 min. The mixture was extracted with EtOAc (30 mL*2). The aqueous phase was acidified with HCl (5 M) until pH=1 and the solution was extracted with EtOAc (30 mL*2). The combined organic phase was dried over Na2SO4 and filtered. The filtrate was concentrated under reduced pressure to give the crude product (4-fluoro-2,6-dimethylphenyl)boronic acid (500 mg).
 

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