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Chemical Structure| 1389287-35-7 Chemical Structure| 1389287-35-7

Structure of 1389287-35-7

Chemical Structure| 1389287-35-7

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Product Details of [ 1389287-35-7 ]

CAS No. :1389287-35-7
Formula : C14H12FNO2
M.W : 245.25
SMILES Code : O=C(C1=C(F)C(C2=CC=CC=C2)=CC=C1N)OC
MDL No. :N/A

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Application In Synthesis of [ 1389287-35-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1389287-35-7 ]

[ 1389287-35-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 206551-41-9 ]
  • [ 89415-43-0 ]
  • [ 1389287-35-7 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In 1,2-dimethoxyethane; at 85℃; for 10h; To a solution of Example 223A (3.1 g, 13 mmol) in dimethoxyethane (25 mL) was added (4-aminophenyl)boronic acid (2.77 g, 16 mmol) and Na2CO3 (3.38 g, 31.2 mmol) in water (6 mL) followed by 1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride:dichloromethane:complex (652 mg, 0.8 mmol). The mixture was heated to 85° C. for 10 hours. After cooling to room temperature, the reaction mixture was partitioned between water and ethyl acetate. The organic phase was washed with water followed by brine then dried over magnesium sulfate. After filtration and concentration, the crude product was purified by flash chromatography (1percent-100percent ethyl acetate/hexane) to provide the title compound.
 

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