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Chemical Structure| 1383847-34-4 Chemical Structure| 1383847-34-4

Structure of 1383847-34-4

Chemical Structure| 1383847-34-4

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Product Details of [ 1383847-34-4 ]

CAS No. :1383847-34-4
Formula : C6H4BrF2NO
M.W : 224.00
SMILES Code : O=C1C(C(F)F)=CC(Br)=CN1

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Application In Synthesis of [ 1383847-34-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1383847-34-4 ]

[ 1383847-34-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1254123-51-7 ]
  • [ 1383847-34-4 ]
YieldReaction ConditionsOperation in experiment
95% With hydrogen bromide; acetic acid; at 20 - 50℃; for 6.66667h; Example 23i 5-Bromo-3-(difluoromethyl)pyridin-2(1H)-one Hydrobromic acid (33% in glacial acetic acid) (63.4 mL, 361 mmol) was added to <strong>[1254123-51-7]5-bromo-3-(difluoromethyl)-2-methoxypyridine</strong> (6.37 g, 26.8 mmol, Example 22i). The resulting reaction mixture was stirred at r.t. for 5 h, then at 40 C. for 75 min, then at 50 C. for 25 min. The reaction was allowed to cool, then the reaction mixture was concentrated in vacuo. The residue was partitioned between NaHCO3 (aq. sat.) and CHCl3. The aqueous phase was extracted twice with CHCl3, the combined organics were passed through a phase separator and concentrated to give the title compound (5.68 g, 95% yield). 1H NMR (500 MHz, DMSO-d6) δ ppm 6.81 (t, 1H), 7.78-7.83 (m, 1H), 7.89 (m, 1H), 12.46 (br. s., 1H); MS (ES+) m/z 224 [M+H]+.
  • 2
  • [ 103058-87-3 ]
  • [ 1383847-34-4 ]
 

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