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Chemical Structure| 1380649-07-9 Chemical Structure| 1380649-07-9

Structure of 1380649-07-9

Chemical Structure| 1380649-07-9

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Product Details of [ 1380649-07-9 ]

CAS No. :1380649-07-9
Formula : C10H9N3O3
M.W : 219.20
SMILES Code : O=C(C1=NOC(C2=NC=CC=N2)=C1)OCC
MDL No. :MFCD32708677

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Application In Synthesis of [ 1380649-07-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1380649-07-9 ]

[ 1380649-07-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 14337-43-0 ]
  • [ 37972-24-0 ]
  • [ 1380649-07-9 ]
YieldReaction ConditionsOperation in experiment
59% With triethylamine; In toluene; at 90℃; for 0.5h; Preparation 2: 2-(3-Bromomethyl-isoxazol-5-yl)-pyrimidine:Step- 1 : 2-(3-Ethoxycarbonyl-isoxazol-5-yl)-pyrimidine:To a mixture of <strong>[37972-24-0]2-ethynyl-pyrimidine</strong> (28 gm) and ethylchlorooxamidoacetate (45 gm) in toluene (340 ml) was added triethylamine (42 ml) at 90C, and it was stirred for 0.5 h. The reaction was monitored by TLC. Reaction was allowed to cool at 30C and water was added. Organic layers were separated. Organic layer was evaporated under vacuum and the crude mass was triturated with n-hexane. The suspension was filtered and the wet cake washed with small quantity of n-hexane to provide title compound in 35.1 gm quantity (59%) as a cream colored solid.Mass: m/z: 220.1 (M+l)
  • 2
  • [ 95080-93-6 ]
  • [ 37972-24-0 ]
  • [ 1380649-07-9 ]
YieldReaction ConditionsOperation in experiment
0.07 g With triethylamine; In diethyl ether; at 20℃; for 3h; To a mixture of (Z)-ethyl 2-chloro-2-(hydroxyimino) acetate (200 mg, l.2lm mole, 1 eq) and 2- ethynylpyrimidine (252.1 mg, 1.21 mmol, 1 equiv.) in ether (80 mL) at room temperature was added a solution of TEA (0.337 mL, 2.42 mmol, 2.0 equiv.) in ether (20 mL) drop wise over 60 minutes. The reaction mixture was stirred for 2 h at room temperature. The reaction mixture was filtered, and the filtrate was concentrated to yellow oil which was purified by flash silica gel chromatography using a mixture of ethyl acetate in hexane to afford ethyl 5- (pyrimidin-2-yl) isoxazole-3-carboxylate as a white solid (0.07 g). LCMS: 220 [M+H] +.
 

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