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Chemical Structure| 1380324-08-2 Chemical Structure| 1380324-08-2

Structure of 1380324-08-2

Chemical Structure| 1380324-08-2

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Product Details of [ 1380324-08-2 ]

CAS No. :1380324-08-2
Formula : C12H11ClN2O2
M.W : 250.68
SMILES Code : O=C1C=C(O)C=C(C)N1C2=CC(Cl)=NC=C2C

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Application In Synthesis of [ 1380324-08-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1380324-08-2 ]

[ 1380324-08-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 675-10-5 ]
  • [ 79055-62-2 ]
  • [ 1380324-08-2 ]
YieldReaction ConditionsOperation in experiment
With lithium chloride; at 160℃; for 0.333333h;Sealed tube; Step 1: Preparation of 2'-chloro-4-hydroxy-5',6-dimethyl-2H-1,4'-bipyridin-2-one. A well-powdered mixture of <strong>[79055-62-2]4-amino-5-methyl-2-chloropyridine</strong> (0.5 g, 3.5 mmol), 4-hydroxy-6-methyl-pyrone (0.665 g, 5.3 mmol), and lithium chloride (0.025 g, 0.6 mmol) was heated at 160° C. for 20 min in a sealed tube. The resulting melt was cooled and the product was isolated by silica gel flash chromatography using 3percent methanol in dichloromethane. Appropriate fractions were combined, concentrated under reduced pressure and the resulting solid was triturated with ethyl acetate, cooled and filtered. The solid was washed with ethyl acetate and dried to give 0.053 g of the title compound as a yellow powder. ES-MS: m/z=251 (M+H).NMR 1H (300 MHz), CDCl3 delta: 10.80 (br 1H), 8.47 (s, 1H), 7.56 (s, 1H), 5.97 (br, 1H), 5.57 (d, 1H, J=2.4 Hz), 1.96 (s, 3H), and 1.83 (s, 3H).
 

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