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Chemical Structure| 1374249-66-7 Chemical Structure| 1374249-66-7

Structure of 1374249-66-7

Chemical Structure| 1374249-66-7

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Product Details of [ 1374249-66-7 ]

CAS No. :1374249-66-7
Formula : C18H12BrNO3
M.W : 370.20
SMILES Code : O=C(OC)C1=CC=C(C(C2=NC=C(Br)C3=C2C=CC=C3)=O)C=C1
MDL No. :MFCD27922520

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Application In Synthesis of [ 1374249-66-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1374249-66-7 ]

[ 1374249-66-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 66728-98-1 ]
  • [ 76469-88-0 ]
  • [ 1374249-66-7 ]
YieldReaction ConditionsOperation in experiment
General procedure: A 1.0M of NaHMDS in THF (2.60ml, 2.60mmol) was added to a solution of 9 (286mg, 1.23mmol) in THF (2ml) at 0C, and the mixture was stirred for 30min. To the mixture was added a solution of methyl 1-chlorosioquinoline-4-carboxylate (300mg, 1.35mmol) in THF (3ml) and the mixture was stirred at room temperature for 2.5h. Then, the reaction mixture was further stirred for 17h under oxygen atmosphere. The reaction was quenched by adding a saturated ammonium chloride solution, and the mixture was extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (NH) eluting with 10-30% EtOAc/hexane to give 10 (289mg, 58%) as a yellow amorphous
 

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• Acyl Group Substitution • Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bouveault-Blanc Reduction • Bucherer-Bergs Reaction • Catalytic Hydrogenation • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Ester Cleavage • Fischer Indole Synthesis • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Reactions with Organometallic Reagents • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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