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Chemical Structure| 1365803-10-6 Chemical Structure| 1365803-10-6

Structure of 1365803-10-6

Chemical Structure| 1365803-10-6

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Product Details of [ 1365803-10-6 ]

CAS No. :1365803-10-6
Formula : C15H20BFO3
M.W : 278.13
SMILES Code : CCC(C1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1F)=O
MDL No. :MFCD26390270

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Application In Synthesis of [ 1365803-10-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1365803-10-6 ]

[ 1365803-10-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 73183-34-3 ]
  • [ 259750-61-3 ]
  • [ 1365803-10-6 ]
YieldReaction ConditionsOperation in experiment
25% With potassium acetate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In 1,4-dioxane; at 80℃; l-(4-Bromo-2-fluorophenyl)propan-l-one (433 mg, 1.874 mmol), bis(pinacolato)diboron (714 mg, 2.81 1 mmol), Pd(dppf 2Ci2 dichloromethane adduct (153 mg, 0.817 mmol) and potassium acetate (552 mg, 5.622 mmol) were suspended in 1,4-dioxane (20 mL). The mixture was stirred at 80 C overnight and then was cooled to room temperature. The mixture was diluted with ethyl acetate, was filtered through a Celite pad and was concentrated. The residue was purified by column chromatography (eluted with hexanes:ethyl acetate= 10: 1) to give l-[2-fluoro-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)phenyl]propan-l-one (103 mg, 0.467 mmol, 25% yield) as a yellow oil. ¾ NMR (400 MHz, CDC13): delta 7.82 (t, 1H), 7.61 (d, 1H), 7.53 (d, 1H), 3.00 (q, 2H), 1.35 (s, 12H), 1.20 (t, 3H).
 

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