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Chemical Structure| 1360883-33-5 Chemical Structure| 1360883-33-5

Structure of 1360883-33-5

Chemical Structure| 1360883-33-5

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Product Details of [ 1360883-33-5 ]

CAS No. :1360883-33-5
Formula : C10H8N2
M.W : 156.18
SMILES Code : N#CC1=C(C)C=CC2=C1C=CN2

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Application In Synthesis of [ 1360883-33-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1360883-33-5 ]

[ 1360883-33-5 ] Synthesis Path-Downstream   1~1

  • 1
  • zinc cyanide [ No CAS ]
  • [ 610794-15-5 ]
  • [ 1360883-33-5 ]
YieldReaction ConditionsOperation in experiment
48.5% With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); zinc; In 1-methyl-pyrrolidin-2-one; at 145℃; for 18h; step 3: A mixture of 300 (150 mg, 0.714 mmol), Pd2(dba)3 (131 mg, 0.143 mmol), dppf (159 mg, 0.286 mmol), Zn(CN)2 (84 mg, 0.714 mmol), and zinc (4.6 mg, 0.0714 mmol) in NMP (10 mL) under nitrogen atmosphere was heated at 145 C for 18 h. The reaction mixture was poured into water (50 mL) and extracted with EtOAc (20 mL x 3). The combined extracts were dried (MgS04), filtered, and concentrated to dryness. The crude was purified by S1O2 chromatography eluting with petroleum ether/EtOAc (3:1) to afford54 mg (48.5%) 5-methyl-lH-indole-4-carbonitrile (302) as yellow solid: MS (ESI) m/z = 157.1 (M+l).
 

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