Home Cart Sign in  
Chemical Structure| 1357572-67-8 Chemical Structure| 1357572-67-8

Structure of 1357572-67-8

Chemical Structure| 1357572-67-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1357572-67-8 ]

CAS No. :1357572-67-8
Formula : C22H14BrN
M.W : 372.26
SMILES Code : BrC1=CC2=C(C=C1)C3=C(C=CC4=CC=CC=C43)N2C5=CC=CC=C5
MDL No. :MFCD29277496
InChI Key :SCFYLUFGTCXFSI-UHFFFAOYSA-N
Pubchem ID :89948175

Safety of [ 1357572-67-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 1357572-67-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1357572-67-8 ]

[ 1357572-67-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 591-50-4 ]
  • [ 1357572-66-7 ]
  • [ 1357572-67-8 ]
YieldReaction ConditionsOperation in experiment
88% With potassium phosphate; copper(l) iodide; trans-1,2-cyclohexanediamine; In 1,4-dioxane;Reflux; F2-3 (purchased) (20g, 67.53mmol), iodobenzene (16.53g, 81.03mmol), trans-1,2-cyclohexadiamine (7.71g, 8.11ml, 67.53mmol), CuI (12.86g, 67.53mmol), K3PO4 (42.96g, 202.59mmol) was put in a 500ml round bottom flask, dissolved in Dioxane (200ml), and stirred under reflux. After completion of the reaction, MC/H2O was extracted. The concentrated organic solvent was adsorbed on silica, followed by column purification and recrystallization. F2-2 (22.12g, 59.43mmol, 88%), D2 (17.76g, 71.31mmol), Pd(dba)2 (1.71g, 2.97mmol), Xphos (2.83g, 5.94mmol), NaOH (4.75g, 118.84mmol) in a 500ml round bottom flask, Dioxane (200ml) )/H2O (40ml) and stirred under reflux. After the reaction was completed, MC/H2O was extracted, followed by column purification and recrystallization. F2-1 (19.21g, 46.35mmol, 78%), Triphenylphosphine (24.31g, 92.70mmol) was dissolved in dichlorobenzene (DCB, dichlorobenzene) (200ml) and stirred under reflux. After the reaction was completed, DCB was sufficiently concentrated, followed by adsorption of silica, followed by column purification and recrystallization. F2 (9.22g, 24.10mmol, 52%) compound was obtained. (During the reaction, F14 was also produced.)
60% With copper(l) iodide; caesium carbonate; ethylenediamine; In toluene; at 120.0℃; for 5h; Compound 1-2 (20.0 g, 67.53 mmol), iodobenzene (15.0 mL, 135.06 mmol), CuT (12.0 g, 33.77 mmol), Cs2CO3 (66.0 g, 202.59 mmol), ethylenediamine (EDA) (2.0 mL, 33.77 mmol), and toluene (400.0 mL) were dissolved in a flask and the mixture was refluxed at 120 C for 5 hrs. After completing the reaction, the organic layer was extracted with EA and dried by removing the remaining moisture with MgSO4. The residue was separated via column chromatography to obtain compound 1-3 (15.0 g, 60%).
40% With copper(l) iodide; caesium carbonate; ethylenediamine; In toluene; for 24h; Preparation of compound 1-3 [122] After adding compound 1-2 (15.5 g, 52.3 mmol), iodobenzene (11.7 mL, 104.7 mmol), CuI (5.0 g, 26.2 mmol), ethylene diamine (EDA) (1.8 mL, 26.2 mmol), and Cs2CO3 (51.2 g, 157.0 mmol) to toluene (250 mL), the reaction mixture was stirred for one day. The reaction mixture was extracted with EA, was distillated under reduced pressure, and was separated through column (MC/Hex) to obtain compound 1-3 (7.9 g, 40 %).
  • 2
  • [ 108-86-1 ]
  • [ 1357572-66-7 ]
  • [ 1357572-67-8 ]
YieldReaction ConditionsOperation in experiment
96.2% With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate; In toluene;Reflux; Inert atmosphere; Under the protection of nitrogen, compound 9 (10g, 371.03g/mol, 26.95mmol), compound 2 (1eq, 155.96g/mol, 26.95mmol, 4.2g), sodium tert-butoxide (1.1eq, 96.1g/mol, 29.65 mmol, 2.85g), Pd2(dba)3 (5%eq, 915.72g/mol, 1.35mmol, 1.23g), tri-tert-butylphosphine (5%eq, 202.317g/mol, 1.35mmol, 0.27g), Toluene (100g, 10 times the mass of compound 6) was added to the reaction flask, heated to reflux for 10-15h, after the reaction, cooled to room temperature, added water, stirred for 10-30min, filtered, the filtrate was separated, the organic phase was dried and passed through silica gel The second filtrate was obtained from the funnel, concentrated under reduced pressure and dissolved in dichloromethane, and purified by column chromatography to obtain compound 10 (11.59 g, yield 96.2%),
 

Historical Records

Technical Information

Categories