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Chemical Structure| 1353776-83-6 Chemical Structure| 1353776-83-6

Structure of 1353776-83-6

Chemical Structure| 1353776-83-6

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Product Details of [ 1353776-83-6 ]

CAS No. :1353776-83-6
Formula : C9H8BrNO
M.W : 226.07
SMILES Code : N#CC1=CC(OCC)=CC=C1Br
MDL No. :MFCD23161987

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Application In Synthesis of [ 1353776-83-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1353776-83-6 ]

[ 1353776-83-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 75-03-6 ]
  • [ 189680-06-6 ]
  • [ 1353776-83-6 ]
YieldReaction ConditionsOperation in experiment
100% With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; for 16.0h;Inert atmosphere; 1006201 Step A: Preparation of 2-bromo-5-ethoxybenzonitrile: A round bottom flask and nitrogen inlet was charged with <strong>[189680-06-6]2-bromo-5-hydroxybenzonitrile</strong> (1.50 g, 7.58 mmol) and dry DMF (30 mL). To this was added cesium carbonate (4.94 g, 15.2 mmol) followed by ethyl iodide (1.77 g, 11.4 mmol) and the mixture was stirred at ambient temperature for 16 hours. The mixture was then diluted with water and extracted two times with diethyl ether. The extracts were washed two times with brine, dried over magnesium sulfate and concentrated under reduced pressure to give 2-bromo-5-ethoxybenzonitrile (1.72 g, 100%) as a white solid.
 

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