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Chemical Structure| 1342905-27-4 Chemical Structure| 1342905-27-4

Structure of 1342905-27-4

Chemical Structure| 1342905-27-4

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Product Details of [ 1342905-27-4 ]

CAS No. :1342905-27-4
Formula : C9H12N2O3
M.W : 196.20
SMILES Code : O=C(C1=NN(C2CCOCC2)C=C1)O
MDL No. :MFCD20331054

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Application In Synthesis of [ 1342905-27-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1342905-27-4 ]

[ 1342905-27-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 134419-59-3 ]
  • [ 5932-27-4 ]
  • [ 1342905-27-4 ]
YieldReaction ConditionsOperation in experiment
19% With caesium carbonate; In N,N-dimethyl-formamide; at 80℃; A vial was charged with <strong>[5932-27-4]ethyl-1H-pyrazole-3-carboxylate</strong> (3.74 g, 26.7 mmol), the crude methanesulfonic acid tetrahydro-pyran-4-yl ester (29.4 mmol), Cs2CO3 (17.4 g, 53.4 mmol), and DMF (100 mL). The reaction mixture was heated to 80° C. and stirred overnight. The reaction was then partitioned between CH2Cl2 (250 mL) and water (250 mL), and the organic layer was washed with water (5*250 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure. The crude product containing 2 regioisomers was purified via flash chromatography on silica gel (95:5-50:50 hexanes:EtOAc) and the later eluting isomer was isolated. This was purified on silica gel a second time (85:15-60:40 hexanes:EtOAc) to give the pure desired product (1.14 g, 19percent).
 

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