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Chemical Structure| 1336804-14-8 Chemical Structure| 1336804-14-8

Structure of 1336804-14-8

Chemical Structure| 1336804-14-8

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Product Details of [ 1336804-14-8 ]

CAS No. :1336804-14-8
Formula : C8H5BrFNO3
M.W : 262.03
SMILES Code : O=C(C1=CC=CC([N+]([O-])=O)=C1F)CBr
MDL No. :MFCD23711752

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Application In Synthesis of [ 1336804-14-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1336804-14-8 ]

[ 1336804-14-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 873697-78-0 ]
  • [ 1336804-14-8 ]
YieldReaction ConditionsOperation in experiment
With copper(ll) bromide; In chloroform; ethyl acetate; for 24h;Reflux; By mechanical stirring (33.9g, 152mmol, 1.9equiv) was suspended / dissolved bromide, copper (II) in ethyl acetate (75mL) in.Was then added in CHCl3Form (75mL) solution of 1- (2-fluoro-3-nitrophenyl) ethanone (14.4g, 80.0mmol, 1equiv), and the reaction was heated to reflux for 24 hours.The reaction was cooled to room temperature and filtered through a silica gel short blocks, washed with ethyl acetate.The filtrate was evaporated, leaving crude 2-bromo-1- (2-fluoro-3-nitrophenyl) ethanone, it is dissolved in dimethyl acetamide (150 mL) and 2,2-dimethyl thioamide propane (10.3g, 88.0mmol, 1 equiv) in.The reaction was stirred at room temperature for 1.5 hours.The reaction was heated to 60 2 hours, cooled to room temperature, and washed with water (300mL) was diluted.(2x200mL) and the mixture extracted with 15% MTBE in heptane.The combined organic layers were washed with brine, in Na2SO4Dried, filtered and evaporated.Using 0-15% ethyl acetate in heptane eluting crude material was purified by silica gel column chromatography.The component containing the product was evaporated to give an off-white solid of 2- (t-butyl) -4- (2-fluoro-3-nitrophenyl) thiazole (15.6g, 70% yield in two steps )
 

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