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Chemical Structure| 1332703-46-4 Chemical Structure| 1332703-46-4

Structure of 1332703-46-4

Chemical Structure| 1332703-46-4

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Product Details of [ 1332703-46-4 ]

CAS No. :1332703-46-4
Formula : C10H7BrN2O
M.W : 251.08
SMILES Code : OCC#CC1=CN=C2C=CC(Br)=CN21

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Application In Synthesis of [ 1332703-46-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1332703-46-4 ]

[ 1332703-46-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 474706-74-6 ]
  • [ 107-19-7 ]
  • [ 1332703-46-4 ]
YieldReaction ConditionsOperation in experiment
92% With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 20℃; for 3h;Inert atmosphere; General procedure: To a solution of <strong>[474706-74-6]6-bromo-3-iodoimidazo[1,2-a]pyridine</strong> (14 or 16) (14: 100 mg or 16: 81 mg, 0.250 mmol) in 2 mL of a mixture of DMF/Et3N (1/1, v/v) were successively added the desired alkyne (0.501 mmol), copper iodide (0.050 mmol) and 8.7 mg (0.012 mmol) of bis(triphenylphosphine)palladium dichloride. The reaction was stirred at room temperature sealed under argon. Once TLC indicated complete consumption of starting material (3 h), the reaction was quenched with water and extracted with dichloromethane (2×15 mL). The combined organic layer were dried over magnesium sulfate and concentrated in vacuo. The resulting residue was purified by column chromatography on silica gel (EtOAc/PE) to afford the corresponding cross-coupling products 15, 17-20, and 22-24.
 

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