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Chemical Structure| 133171-74-1 Chemical Structure| 133171-74-1

Structure of 133171-74-1

Chemical Structure| 133171-74-1

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Product Details of [ 133171-74-1 ]

CAS No. :133171-74-1
Formula : C11H21NO4
M.W : 231.29
SMILES Code : O=C(OC(C)(C)C)N(CCCC(OC)=O)C
MDL No. :MFCD14635755

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Application In Synthesis of [ 133171-74-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 133171-74-1 ]

[ 133171-74-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 6976-17-6 ]
  • [ 18107-18-1 ]
  • [ 133171-74-1 ]
YieldReaction ConditionsOperation in experiment
78% 4-(Methylamino)butyric acid hydrochloride (1.0 g, 6.51 mmol) and di-tert-butyl dicarbonate (1.797 mL, 7.81 mmol) were stirred in dioxane (50 mL) and water (10 mL) containing triethylamine (1.361 mL, 9.77 mmol) at 23° C. for 3 h. The solvent was evaporated. The residue was dissolved in EtOAc and washed with 5percent KHSO4, brine and dried over anhydrous Na2SO4. The solvent was evaporated. The residue was then dissolved in methanol (50.0 mL) at 0° C. and (trimethylsilyl)diazomethane (9.77 mL, 19.53 mmol) was added dropwise to the stirring solution until a light yellow color persisted. The solution was then stirred at 23° C. for 15 min. The solvent was evaporated. The residue was dissolved in EtOAc and washed with 5percent KHSO4, aqueous saturated NaHCO3, brine and dried over anhydrous Na2SO4. The product was purified by flash chromatography using a gradient: 20percent to 50percent EtOAc/heptane. Yield: 1.17 g (78percent); 1H NMR (400 MHz, CHLOROFORM-D) delta 1.45 (s, 9H), 1.84 (ddd, J=14.26, 7.42, 7.23 Hz, 2H), 2.32 (t, J=7.42 Hz, 2H), 2.84 (s, 3H), 3.25 (t, J=6.84 Hz, 2H), 3.68 (s, 3H); MS (ESI) (M+H)+=232.23.
 

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