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Chemical Structure| 131157-26-1 Chemical Structure| 131157-26-1

Structure of 131157-26-1

Chemical Structure| 131157-26-1

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Product Details of [ 131157-26-1 ]

CAS No. :131157-26-1
Formula : C10H13NO3
M.W : 195.22
SMILES Code : CC(NC1=C(OC)C=CC=C1OC)=O
MDL No. :MFCD09909389

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Application In Synthesis of [ 131157-26-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 131157-26-1 ]

[ 131157-26-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2734-70-5 ]
  • [ 108-24-7 ]
  • [ 131157-26-1 ]
YieldReaction ConditionsOperation in experiment
60% In dichloromethane; at 20℃; for 24h;Inert atmosphere; Acetic anhydride (2.97 mL, 31.45 mmol) was added to a solution of aniline 51 (2.19 g, 14.3 mmol) in dry dichloromethane (50 mL) under inert atmosphere. The reaction was stirred at room temperature for 24 hours. Upon completion, the reaction mixture was washed with a saturated solution of sodium carbonate, the organic layer dried over MgSO4 and the solvent removed under reduced pressure. The acetanilide 52 was obtained as a white solid (1.67 g, 60%) after crystallization from Et2O; mp (Et2O) 128-130 C; TLC Rf (EtOAc) = 0.37; 1H NMR (CDCl3, 400 MHz) δ (ppm) 2.20 (large s, 3H, NHCOCH3), 3.84 (s, 6H, 2OCH3), 6.42 (large s, 1H, NHCOCH3), 6.59 (d, J = 8.4 Hz, 2H, ArH), 7.20 (t, J = 8.2 Hz, 1H, ArH). 13C NMR (CDCl3, 100 MHz) δ 23.3 (CH3), 55.9 (2CH3), 104.3 (2CH), 107.4 (C), 127.8 (CH), 155.6 (2C), 172.9 (C). IR ν cm-1: 1104, 1253, 1437, 1474, 1537, 1590, 1651, 3184, 3256. Calcd. for C10H13O3N: C, 61.53; H, 6.71; N, 7.17. Found: C, 61.36; H, 6.94; N, 7.01.
 

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