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Chemical Structure| 1310416-63-7 Chemical Structure| 1310416-63-7

Structure of 1310416-63-7

Chemical Structure| 1310416-63-7

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Product Details of [ 1310416-63-7 ]

CAS No. :1310416-63-7
Formula : C9H12BrNO2
M.W : 246.10
SMILES Code : CCOC1=CC=C(Br)C(OCC)=N1
MDL No. :MFCD19105361

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Application In Synthesis of [ 1310416-63-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1310416-63-7 ]

[ 1310416-63-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 866755-20-6 ]
  • [ 64-17-5 ]
  • [ 1310416-63-7 ]
  • 3-bromo-2-chloro-6-ethoxypyridine [ No CAS ]
  • 3-bromo-6-chloro-2-ethoxypyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium; at 70.0℃; Fresh cut sodium (0.101 g 4.41 mmol) was added to EtOH (50 mL) . The resulting mixture was stirred at rt. After the solid dissolved 3-bromo-2 6-dichloropyridine (1 g 4.41 mmol) was added. The resulting mixture was stirred at 70 overnight. After LCMS analysis showed the starting material was disappeared. The solvent was removed in vacuo. The residue was dissolved in DCM (60 mL) and washed with H2O (20 mL) and brine (20 mL) . The organic layer was dried over Na2SO4 filtered and concentrated. The residue was purified by silica column chromatography (PE/EA 20/1) to yield a white solid of a mixture of 3-bromo-2-chloro-6-ethoxypyridine 3-bromo-2 6-diethoxypyridine and 3-bromo-6-chloro-2-ethoxypyridine (930 mg 3.85 mmol 87yield) 1HNMR(400 MHz CD3OD) delta 7.85 (d J 1.2 Hz 1H) 6.88 (d J 8.0 Hz 1H) 4.42-4.36 (m 2H) 1.39 (t J 7.2 Hz 3H) ES-LCMS m/z 235.9 237.9 (M+H)
 

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