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Chemical Structure| 1307249-61-1 Chemical Structure| 1307249-61-1

Structure of 1307249-61-1

Chemical Structure| 1307249-61-1

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Product Details of [ 1307249-61-1 ]

CAS No. :1307249-61-1
Formula : C10H11BrN2O2
M.W : 271.11
SMILES Code : O=C1N(CC2=CC=CN=C2Br)CCOC1

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Application In Synthesis of [ 1307249-61-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1307249-61-1 ]

[ 1307249-61-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109-11-5 ]
  • [ 94446-97-6 ]
  • [ 1307249-61-1 ]
YieldReaction ConditionsOperation in experiment
66% With sodium hydride;tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; mineral oil; at 20℃; for 16h; PREPARATION 484-[(2-Bromo-3-pyridyl)methyl]<strong>[109-11-5]morpholin-3-one</strong>; To a solution of 2-bromo-3-bromomethyl-pyridine (0.68 g, 2.36 mmol) in dimethylformamide (10 mL) are added sodium hydride (0.11 g, 60% suspension, 2.82 mmol), <strong>[109-11-5]morpholin-3-one</strong> (0.20 g, 1.97 mmol) and tetrabutylammonium iodide (catalytic) at 0 C. The mixture is stirred at room temperature for 16 hours. After completion, the reaction mixture is partitioned between ethyl acetate (25 mL) and water (25 mL). The aqueous layer is extracted with ethyl acetate (2×25 mL) and the combined organic extracts are dried over sodium sulfate and concentrated in vacuo. The crude material is purified by column chromatography over silica gel eluting with hexane/ethyl acetate (55:45) to yield 0.35 g (66%) of the title compound. MS (m/z): 271/273 (M+1, M+3).
 

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