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Chemical Structure| 1303588-33-1 Chemical Structure| 1303588-33-1

Structure of 1303588-33-1

Chemical Structure| 1303588-33-1

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Product Details of [ 1303588-33-1 ]

CAS No. :1303588-33-1
Formula : C10H11ClN2O
M.W : 210.66
SMILES Code : O=C1NC2=C(C=CC(Cl)=N2)C(C)(C)C1
MDL No. :MFCD21607990

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Application In Synthesis of [ 1303588-33-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1303588-33-1 ]

[ 1303588-33-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 618446-06-3 ]
  • [ 1303588-33-1 ]
YieldReaction ConditionsOperation in experiment
50% To a mixture of 7-amino-4,4-dimethyl-3,4-dihydro-l,8-naphthyridin-2(l H)-one (119; 191 mg, 1.0 mmol, 1.0 eq) in 2 mL of concentrated hydrochloric acid at 0C was added a solution of NaN02 in water (386 mg/0.5 mL). After stirring for 30 min, powdered CuCl (150 mg, 1.5 mmol) was added to the above mixture and stirred for 2 hours. Water (5 mL) was added to the reaction mixture and the pH adjusted to -9-10 with NH4OH and then extracted with ethyl acetate (2*). The combined organic layers were washed with water, brine, and concentrated in vacuo to provide a yellow solid. The crude material was loaded onto a silica gel flash column using ethyl acetate/petroleum ether = 10:1 as eluent to afford a yellow solid of 7-chloro-4,4- dimethyl-3,4-dihydro-l,8-naphthyridin-2(lH)-one (120; 105 mg, 50%). MS (ESI) calcd for CioHuCIN20: 210.06.
 

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