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Chemical Structure| 1289267-20-4 Chemical Structure| 1289267-20-4

Structure of 1289267-20-4

Chemical Structure| 1289267-20-4

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Product Details of [ 1289267-20-4 ]

CAS No. :1289267-20-4
Formula : C14H19N3O2
M.W : 261.32
SMILES Code : O=C(N1CC2=NC(C3CC3)=NC=C2C1)OC(C)(C)C
MDL No. :MFCD22565648

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Application In Synthesis of [ 1289267-20-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1289267-20-4 ]

[ 1289267-20-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 157327-42-9 ]
  • [ 57297-29-7 ]
  • [ 1289267-20-4 ]
YieldReaction ConditionsOperation in experiment
64% With triethylamine; In ethanol; at 85℃; for 16h; [00378] Step 2: Synthesis of tert-butyl 2-cyclopropyl-5H-pyrrolo[3, 4-d]pyrimidine- 6(7H)?carboxylate. To a solution of tert-butyl 3-((dimethylamino)methylene)-4- oxopyrrolidine-1- carboxylate (400 mg, 1.67 mmol) in EtOH (15 mL) was addedcyclopropane- carboximidamide HCl (or any other suitably substituted carboximidamide, 8.29 mmol) and Et3N (1.01 g, 10 mmol). The mixture was stirred at 85 °C for 16 h., cooled down to room temperature, the solvent was removed in vacuo and the residue was purified by preparative TLC (petroleum ether/EtOAc = 3/1) to give tert-butyl 2-cyclopropyl-5H- pyrrolo[3,4-d]pyrimidine -6(7H)-carboxylate (280 mg, 64percent yield) as a pale yellow solid. ESI-LCMS (m/z): 262.2[M+1]+.
 

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