Home Cart Sign in  
Chemical Structure| 1268822-64-5 Chemical Structure| 1268822-64-5

Structure of 1268822-64-5

Chemical Structure| 1268822-64-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1268822-64-5 ]

CAS No. :1268822-64-5
Formula : C10H10F2O3
M.W : 216.18
SMILES Code : FC1=C(C(F)=CC(OC)=C1)CC(OC)=O
MDL No. :MFCD28137467

Safety of [ 1268822-64-5 ]

Application In Synthesis of [ 1268822-64-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1268822-64-5 ]

[ 1268822-64-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 67-56-1 ]
  • [ 886498-98-2 ]
  • [ 1268822-64-5 ]
YieldReaction ConditionsOperation in experiment
92% With hydrogenchloride; In water;Heating; Reflux; Methyl 2-(2,6-difluoro-4-methoxyphenyl)acetate (PMW04141)A solution of PMW04140 (3.37 g, 16.7 mmol) in MeOH (70 mL) containing cone. HCl (15 drops) was heated at reflux overnight. The mixture was allowed to cool and was neutralised with sat. aq. NaHCO3. The solvent was removed in vacuo and the residue was dissolved in EtOAc (100 mL) and washed with H2O (100 mL), sat. aq. NaHCO3 (100 mL) and brine (100 mL) then dried (MgSO4) and the solvent was removed in vacuo. The title compound (3JO g, 92%) was obtained as a pale yellow oil; 1H NMR (270 MHz, DMSO-de) 3.61 (2H, s, CH2), 3.69 (3H, s, CH3), 3.76 (3H, s, CH3), 6,40-6 49 (2H, m, ArH); 19F NMR (376.4 MHz, DMSO-d6) 414.4 (d); HRMS (ES+) calcd, for Ci0HnF2O3 (M++H) 217.0657, found 217.0663; LC/MS (ES+) tr = 1.69 min, m/z 216.8 (M+, 100%).
 

Historical Records