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Structure of 1260670-05-0

Chemical Structure| 1260670-05-0

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Product Details of [ 1260670-05-0 ]

CAS No. :1260670-05-0
Formula : C8H4BrClN2
M.W : 243.49
SMILES Code : ClC1=C2N=CC(Br)=CC2=CC=N1
MDL No. :MFCD18250850
InChI Key :DSPVDMUXVYEYPP-UHFFFAOYSA-N
Pubchem ID :72213592

Safety of [ 1260670-05-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 1260670-05-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1260670-05-0 ]

[ 1260670-05-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1375301-90-8 ]
  • [ 1260670-05-0 ]
YieldReaction ConditionsOperation in experiment
1.1 g With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In toluene; at 130.0℃; for 36.0h; 3-Bromo-7H-[1 ,7]naphthyridin-8-one (1.5 g, 6.67 mmol) was suspended in toluene (20 ml). DIPEA (3.5 ml, 20 mmol) and POCI3 (1.8 ml, 20 mmol) were added and the reaction mixture was heated to 130 C for 36 h. The reaction mixture was cooled to rt and partitioned between water (75 ml) and EtOAc (150 ml). The phases were separated and the aq phase was extracted twice with EtOAc (25 ml). The combined organic layer was washed with NaHC03 solution and brine, treated with MgS04 and filtered. The filtrated was concentrated to give the desired product as a beige solid (1 .1 g, 4.52 mmol).HPLC: RtH9= 0.86 min; ESIMS [M+H]+ = 242.8, 244.8, 246.8 (1 Br,1 CI);1H-NMR (400 MHz, DMSO-d6): delta 9.22 (d, 1 H), 8.95 (2, 1 H), 8.49 (d, 1 H), 7.99 (d, 1 H).
 

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Related Functional Groups of
[ 1260670-05-0 ]

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Related Parent Nucleus of
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Naphthyridines

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