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Chemical Structure| 125818-11-3 Chemical Structure| 125818-11-3

Structure of 125818-11-3

Chemical Structure| 125818-11-3

1,7-Dimethyl-1H-indole-3-carboxylic acid

CAS No.: 125818-11-3

4.5 *For Research Use Only !

Cat. No.: A1387234 Purity: 95%

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Product Details of [ 125818-11-3 ]

CAS No. :125818-11-3
Formula : C11H11NO2
M.W : 189.21
SMILES Code : O=C(C1=CN(C)C2=C1C=CC=C2C)O
MDL No. :MFCD11617127

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Application In Synthesis of [ 125818-11-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 125818-11-3 ]

[ 125818-11-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 30448-16-9 ]
  • [ 74-88-4 ]
  • [ 125818-11-3 ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide; In acetone; (a) 1,7-Dimethylindole-3-carboxylic acid Methyl iodide (30 g) was added to a stirred mixture of <strong>[30448-16-9]7-methylindole-3-carboxylic acid</strong> (4.3 g) and powdered potassium hydroxide (20 g) in anhydrous acetone at 0 C. The resulting suspension was then stirred at room temperature overnight, then poured into water (500 ml), washed with dichloromethane (3*100 ml) and the aqueous phase acidified to pH 2 with hydrochloric acid. The product was isolated by filtration and dried under vacuum to afford white crystals (4.5 g); m.p. 243 C.; deltaH (360 MHz, DMSO-d6) 2.72 (3H, s, CH3), 4.09 (3H, s, NCH3), 6.92 (1H, d, J=6 Hz, H-6), 7.02 (1H, t, J=6 Hz, H-5), 7.87 (1H, d, J=6, H-4), 7.92 (1H, s, H-2); m/z 189 (M+, 100%), 172 (40), 144 (30), 91 (55).
 

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