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Chemical Structure| 1256958-60-7 Chemical Structure| 1256958-60-7

Structure of 1256958-60-7

Chemical Structure| 1256958-60-7

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Product Details of [ 1256958-60-7 ]

CAS No. :1256958-60-7
Formula : C13H19BN2O4
M.W : 278.11
SMILES Code : CC1(C)C(C)(C)OB(C2=CC=C([N+]([O-])=O)C(NC)=C2)O1

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Application In Synthesis of [ 1256958-60-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1256958-60-7 ]

[ 1256958-60-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 302800-13-1 ]
  • [ 73183-34-3 ]
  • [ 1256958-60-7 ]
YieldReaction ConditionsOperation in experiment
With potassium acetate;Pd(dppf); In 1,4-dioxane; at 80℃; for 3h;Inert atmosphere; [000203] 5-Bromo-N-methyl-2-nitroaniline (1 eqvt), bis(pinacolatodiboron) (1.2 eqvt), and potassium acetate (2 eqvt) were combined in dioxane (0.15 M) and degassed 3x replacing the air with nitrogen gas. Pd(dppf) (0.1 eqvt) was added and degassing was done once more. The reaction mixture was heated to 80 C for three hours. The mixture was then cooled to room temperature and partitioned between water and ethyl acetate. The organic fraction was washed with brine, then concentrated onto silica gel and purified by chromatography to provide the title compound. MS (m/z): 317.2 (M + K)+. 1HNMR (DMSO-d6, 400 MHz) δ 8.1 1 (bd, J = 4.8 Hz, 1H), 8.01 (d, J = 8.8 Hz, 1H), 7.16 (d, J = 0.8 Hz, 1H), 6.87 (dd, J = 8.4, 0.8 Hz, 1H), 2.93 (d, J = 4.8, 3H), 1.28 (s, 12 H).
 

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