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Chemical Structure| 124506-31-6 Chemical Structure| 124506-31-6

Structure of 124506-31-6

Chemical Structure| 124506-31-6

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Product Details of [ 124506-31-6 ]

CAS No. :124506-31-6
Formula : C5H10O2
M.W : 102.13
SMILES Code : OC[C@@H]1COCC1
MDL No. :MFCD17015962
InChI Key :PCPUMGYALMOCHF-RXMQYKEDSA-N
Pubchem ID :40488404

Safety of [ 124506-31-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H227-H315-H319-H335
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 124506-31-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 124506-31-6 ]

[ 124506-31-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 168395-26-4 ]
  • [ 124506-31-6 ]
YieldReaction ConditionsOperation in experiment
Example 5 5-Butyl-9-[1-(2,4-dimethyl-pyridine-3-carbonyl)-4-methyl-piperidin-4-yl]-3-[(R)-1-(tetrahydro-furan-3-yl)methyl]-3,9-diaza-spiro[5.5]undecan-2-one (I-14) step 1-(S)-Tetrahydro-3-furanoic acid (3.3 g, 29.1 mmol) was dissolved in freshly distilled THF (15 mL) and added to a slurry of NaBH4 (2.6 g, 69 mmol) in freshly distilled THF (15 mL) cooled to 0 C. and maintained under a N2 atmosphere. The mixture was stirred for 10 min and then a solution of I2 (7.3 g, 29 mmol) in anhydrous THF (15 mL) was added dropwise over a 30 min period. When gas evolution ceased the solution was heated at reflux for 12 h. The reaction mixture was cooled, the solvent evaporated and the residue was taken up in 20% aqueous KOH and stirred for 4 h at RT. The aqueous solution was continuously extracted with DCM for 2 d and the resulting extract was dried (MgSO4), filtered and evaporated to afford 2.5 g of (R)-20: MS=(M+H)=103; NMR=1H nmr δ 3.93-3.51 (m, 6H), 2.2-2.0 (m, 1H), 1.98-1.71 (m, 2H).
 

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