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Chemical Structure| 1243284-44-7 Chemical Structure| 1243284-44-7

Structure of 1243284-44-7

Chemical Structure| 1243284-44-7

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Product Details of [ 1243284-44-7 ]

CAS No. :1243284-44-7
Formula : C10H11ClO2
M.W : 198.65
SMILES Code : OC1=CC=C(C(Cl)=C1)OCC2CC2
MDL No. :MFCD17000220

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Application In Synthesis of [ 1243284-44-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1243284-44-7 ]

[ 1243284-44-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 7051-34-5 ]
  • [ 615-67-8 ]
  • [ 1243284-44-7 ]
YieldReaction ConditionsOperation in experiment
17% With potassium carbonate; In N,N-dimethyl-formamide; at 80℃; for 8h; Step 1 Preparation of Compound 26 (0564) Potassium carbonate (4.78 g, 34.6 mmol) and (bromomethyl)cyclopropane (2.03 mL, 20.8 mmol) were added to the DMF solution (10 ml) of Compound 25 (2.0 g, 13.8 mmol), and the mixture was stirred at 80 C. for 8 hours. Water was added to the mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate. The solvent was condensed under reduced pressure. The residue was purified by silica gel chromatography (hexane-ethyl acetate) to afford Compound 26 (470 mg, yield 17%). (0565) 1H-NMR (CDCl3) delta: 6.89 (d, J=3.0 Hz, 1H), 6.83 (d, J=8.7 Hz, 1H), 6.66 (dd, J=8.8, 2.9 Hz, 1H), 4.56 (s, 1H), 3.81 (d, J=6.7 Hz, 2H), 1.34-1.21 (m, 1H), 0.65-0.59 (m, 2H), 0.37-0.32 (m, 2H).
 

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