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Chemical Structure| 1231765-07-3 Chemical Structure| 1231765-07-3

Structure of 1231765-07-3

Chemical Structure| 1231765-07-3

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Product Details of [ 1231765-07-3 ]

CAS No. :1231765-07-3
Formula : C16H13FOS
M.W : 272.34
SMILES Code : O=C1CCCC2=C1C=CC(SC3=CC=CC(F)=C3)=C2

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Application In Synthesis of [ 1231765-07-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1231765-07-3 ]

[ 1231765-07-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 703-67-3 ]
  • [ 2557-77-9 ]
  • [ 1231765-07-3 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In 1-methyl-pyrrolidin-2-one; at 90℃; for 20h; Step 4 6-(3-Fluoro-phenylsulfanyl)-3,4-dihydro-2H-naphthalen-1-one A solution of <strong>[703-67-3]6-fluoro-3,4-dihydro-2H-naphthalen-1-one</strong> (3.64 kg) and 3-fluorothiophenol (2.80 kg), in anhydrous NMP (7.7 kg) was treated with triethylamine (2.26 kg). After a mild exotherm had subsided, the mixture was heated for 20 hours at 90° C. The mixture was cooled to about 25° C. and diluted with water (30 L) and heptane (10 kg). The mixture was agitated for 12 hours and then filtered. The filter cake was washed with water and dried at 60° C. under vacuum to afford 6-(3-fluorophenylsulfanyl)-3,4-dihydro-2H-naphthalen-1-one (5.52 kg): MP=66.2-66.7° C.; MS (M+1)=273; H1 NMR (300 MHz): delta ppm (CDCl3): 2.10 (2H, m, J=6.03, 6.40 Hz), 2.62 (2H, dd, J=6.03, 5.75 Hz) 2.87 (2H, t, J=6.03), 7.03 (1H,tdd, J=1.13, 2.64, 8.29 Hz), 7.08-7.16 (2H, m), 7.22 (1H, dt, J=1.13, 8.29 Hz), 7.31 (1H, q, 8.29 Hz), 7.35 (1H, dd, J=5.65, 7.91 Hz) 7.92(1H, d, J=7.91 Hz).
 

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