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Chemical Structure| 1226694-16-1 Chemical Structure| 1226694-16-1

Structure of 1226694-16-1

Chemical Structure| 1226694-16-1

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Product Details of [ 1226694-16-1 ]

CAS No. :1226694-16-1
Formula : C15H19N3O
M.W : 257.33
SMILES Code : COC1=CC=C2C=CC=NC2=C1N3CCNCCC3
MDL No. :MFCD20486572

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Application In Synthesis of [ 1226694-16-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1226694-16-1 ]

[ 1226694-16-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 505-66-8 ]
  • [ 36023-06-0 ]
  • [ 1226694-16-1 ]
YieldReaction ConditionsOperation in experiment
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); In toluene; for 4.0h;Reflux; Inert atmosphere; Step 4: 8-[l,4]Diazepan-l-yl-7-methoxy-quinolinehomopiperazine Pd2(dba)3, BINAP, NaOfBu, toluene [0154] A mixture of 8-bromo-7-hydroxyquinoline (126 g , 0.488 mol), homopiperazine (201g , 2.0 mol), (+/-)-BINAP (19.8 g , 31.8 mmol), and sodium tert-butoxide (75.6 g , 0.786 mol) was suspended in 900 mL of toluene and purged with nitrogen gas for an hour. Tris- benzylidineacetone dipalladium(O) (9.7 g, 10.6 mmol) was added. The mixture was purged for another hour, heated to reflux under nitrogen for 4 hr, cooled to rt, carefully diluted with 1300 mL of 20% AcOH in water and filtered through 100 g of celite. The celite pad was washed with 20% AcOH in water (IL x 2) and ethyl acetate (1 L x 1). The aqueous phase was extracted with ethyl acetate (I L x 4), adjusted to pH 10 -11 with NaOH (10 N, 500 mL), and then extracted with a mixture Of CH2Cl2 and iPrOH (80:20, 1 L x 2 and 0.5 L x 4). The combined organic phase was washed with saline (400 mL), dried over Mg2SO4 and evaporated to give the desired product (98 g).
 

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