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Chemical Structure| 1223444-94-7 Chemical Structure| 1223444-94-7

Structure of 1223444-94-7

Chemical Structure| 1223444-94-7

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Product Details of [ 1223444-94-7 ]

CAS No. :1223444-94-7
Formula : C7H8ClN3O2
M.W : 201.61
SMILES Code : O=C(C1=NC=CN=C1Cl)N(OC)C

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Application In Synthesis of [ 1223444-94-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1223444-94-7 ]

[ 1223444-94-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6638-79-5 ]
  • [ 27398-39-6 ]
  • [ 1223444-94-7 ]
YieldReaction ConditionsOperation in experiment
To a suspension of <strong>[27398-39-6]3-chloropyrazine-2-carboxylic acid</strong> (5.46 g) in THF (100 mL) was added CDI (6.14 g) at room temperature, and the mixture was stirred at room temperature for 30 min and heated to 50 °C. After stirring at 50 °C for 1 h, the mixture was cooled to room temperature. To the mixture were added N, O-dimethylhydroxylamine hydrochloride (5.04 g) and DIPEA (9.02 mL) at room temperature, and the mixture was stirred at room temperature overnight. The mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (3.05 g) .MS (API+) : [M+H]+ 202.1.H NMR (300 MHz, CDC13) delta 3.43 (3H, s) , 3.58 (3H, s), 8.44 (1H, d, J = 2.3 Hz>, 8.52 (1H, d, J = '2.3 Hz).
 

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