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Chemical Structure| 1219720-20-3 Chemical Structure| 1219720-20-3

Structure of 1219720-20-3

Chemical Structure| 1219720-20-3

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Product Details of [ 1219720-20-3 ]

CAS No. :1219720-20-3
Formula : C14H15BN2O4
M.W : 286.09
SMILES Code : O=C(CN(C)C1)OB(C(N2C)=CC3=C2C=CC=C3)OC1=O
MDL No. :MFCD22417211

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Application In Synthesis of [ 1219720-20-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1219720-20-3 ]

[ 1219720-20-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4408-64-4 ]
  • [ 191162-40-0 ]
  • [ 1219720-20-3 ]
YieldReaction ConditionsOperation in experiment
93% In dimethyl sulfoxide; benzene; for 3h;Inert atmosphere; Reflux; To form protected organoboronic acid 2j, the general procedure was followed using N-methylindole-2-boronic acid (3.00 g, 17.1 mmol), N-methyliminodiacetic acid (2.77 g, 18.9 mmol), benzene (60 mL) and DMSO (30 mL). The mixture was refluxed for 3 h. The product was eluted with Et2θ:MeCN 2:1 to afford the boronate ester 2j as a colorless crystalline solid (4.55 g, 93%). TLC (EtOAc) Rf = 0.39, visualized by UV (254 nm) and KMnO4. 1H-NMR (500 MHz, CD3CN) δ 7.57 (app dt, / = 8.0, 1.0 Hz, 1 H), 7.39 (dd, / = 8.0, 1.0 Hz, 1 H), 7.20 (ddd, / = 8.0, 7.0, 1.0 Hz, 1 H), 7.04 (ddd, / = 8.0, 7.0, 1.0 Hz, 1 H), 6.66 (d, / = 1.0 Hz, 1 H), 4.07 (d, / = 1 7 Hz, 2H), 3.92 (d, / = 1 7 Hz, 2H), 3.82 (s, 3H), 2.56 (s, 3H). 13C-NMR (125 MHz, CD3CN) δ 169.4, 141.3, 129.0, 122.9, 121.5, 120.0, 1 1 1.4, 1 10.6, 62.3, 47.8, 32.8. 11 B-NMR (96 MHz, CD3CN) δ 10.8. HRMS (EI +) Calculated for C14H15BN2O4 (M) + : 286.1 125, Found: 286.1 127. IR (thin film, cm -1) 3000, 2948, 1765, 1653, 1617, 1508, 1456, 1509, 1456, 1360, 1332, 1276, 1236, 1 161 , 1037, 998, 962, 897, 859.
 

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