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Chemical Structure| 1219432-58-2 Chemical Structure| 1219432-58-2

Structure of 1219432-58-2

Chemical Structure| 1219432-58-2

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Product Details of [ 1219432-58-2 ]

CAS No. :1219432-58-2
Formula : C16H19BrN2O4
M.W : 383.24
SMILES Code : O=C(O)C(CC1=CNC2=C(Br)C=CC=C12)NC(OC(C)(C)C)=O
MDL No. :MFCD09750490

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Application In Synthesis of [ 1219432-58-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1219432-58-2 ]

[ 1219432-58-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 852391-45-8 ]
  • [ 24424-99-5 ]
  • [ 1219432-58-2 ]
YieldReaction ConditionsOperation in experiment
9.90 g With sodium hydroxide; In tetrahydrofuran; water; at 20.0℃; To a solution of rac-18 in dioxane (60 ml) was added HCl (6 M,60ml). The reaction mixture was heated to reflux for 6 h before the solvent was removed in vacuo. The crude residue was dissolved in NaOH (aqueous, 3 M, 50 ml). Then water (100 ml), THF (150 ml), Boc2O (9.2 g, 42.2 mmol) was added and the reaction mixture was stirred at rt overnight. The solvent was removed in vacuo and the resulting mixture was diluted with EtOAc. The organic layer was washed with H2O and brine, dried over Na2SO4, and concentratedto give rac-19 (9.90 g, 70%) was brown solid. The crude residue used directly for the next step without further purification.
 

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